Franchise 57 seasons 446–445–6 all-time 20 playoff trips 3 Super Bowls
2021 players
Passing
| Derek Carr | 626 | 428 | 4,804 | 23 | 14 | 7.7 |
| Marcus Mariota | 2 | 1 | 4 | 0 | 0 | 2.0 |
Rushing
| Josh Jacobs | 217 | 872 | 9 | 4.0 |
| Kenyan Drake | 63 | 254 | 2 | 4.0 |
| Peyton Barber | 55 | 212 | 2 | 3.9 |
| Derek Carr | 40 | 108 | 0 | 2.7 |
| Marcus Mariota | 13 | 87 | 1 | 6.7 |
| Jalen Richard | 9 | 40 | 0 | 4.4 |
| Henry Ruggs III | 3 | 16 | 0 | 5.3 |
| Trey Ragas | 1 | 9 | 0 | 9.0 |
| Dallin Leavitt | 2 | 6 | 0 | 3.0 |
| DeSean Jackson | 1 | 4 | 0 | 4.0 |
| Zay Jones | 2 | 3 | 0 | 1.5 |
| Hunter Renfrow | 3 | 3 | 0 | 1.0 |
| Nathan Peterman | 2 | 2 | 0 | 1.0 |
| Alec Ingold | 2 | 1 | 0 | 0.5 |
| Bryan Edwards | 1 | 0 | 0 | 0.0 |
Receiving
| Hunter Renfrow | 128 | 103 | 1,038 | 9 | 8.1 |
| Darren Waller | 93 | 55 | 665 | 2 | 7.2 |
| Bryan Edwards | 59 | 34 | 571 | 3 | 9.7 |
| Zay Jones | 70 | 47 | 546 | 1 | 7.8 |
| Henry Ruggs III | 36 | 24 | 469 | 2 | 13.0 |
| DeSean Jackson | 34 | 20 | 454 | 2 | 13.4 |
| Foster Moreau | 44 | 30 | 373 | 3 | 8.5 |
| Josh Jacobs | 64 | 54 | 348 | 0 | 5.4 |
| Kenyan Drake | 40 | 30 | 291 | 1 | 7.3 |
| Alec Ingold | 12 | 10 | 85 | 1 | 7.1 |
| Jalen Richard | 14 | 12 | 72 | 0 | 5.1 |
| Peyton Barber | 13 | 10 | 67 | 0 | 5.2 |
| Tyron Johnson | 5 | 2 | 16 | 0 | 3.2 |
| Derek Carrier | 2 | 2 | 13 | 0 | 6.5 |
| Trey Ragas | 2 | 2 | 6 | 0 | 3.0 |
| Daniel Helm | 2 | 1 | -1 | 0 | -0.5 |
Defense
| Denzel Perryman | MLB | 146 | 94 | 0.0 | 0 | 3 | 1 |
| Johnathan Abram | DB | 107 | 55 | 0.0 | 1 | 4 | 0 |
| Cory Littleton | ILB | 93 | 46 | 0.5 | 0 | 4 | 0 |
| Nate Hobbs | CB | 71 | 48 | 1.0 | 1 | 3 | 1 |
| Tre'von Moehrig | SAF | 54 | 35 | 0.0 | 1 | 6 | 0 |
| Brandon Facyson | DB | 51 | 38 | 0.0 | 1 | 13 | 0 |
| K.J. Wright | OLB | 46 | 20 | 0.0 | 0 | 0 | 0 |
| Maxx Crosby | DE | 46 | 26 | 8.0 | 0 | 7 | 0 |
| Casey Hayward | CB | 44 | 37 | 0.0 | 1 | 9 | 0 |
| Quinton Jefferson | DE | 43 | 13 | 4.5 | 0 | 1 | 2 |
| Divine Deablo | LB | 39 | 22 | 0.0 | 0 | 1 | 0 |
| Johnathan Hankins | DT | 37 | 14 | 0.0 | 0 | 1 | 0 |
| Dallin Leavitt | DB | 33 | 15 | 0.0 | 0 | 2 | 0 |
| Solomon Thomas | DE | 32 | 15 | 3.5 | 0 | 2 | 2 |
| Yannick Ngakoue | DE | 25 | 14 | 10.0 | 0 | 3 | 2 |
| Darius Philon | DT | 24 | 16 | 2.0 | 0 | 2 | 0 |
| Nick Kwiatkoski | ILB | 20 | 12 | 0.0 | 0 | 0 | 1 |
| Trayvon Mullen | CB | 19 | 16 | 0.0 | 1 | 4 | 0 |
| Carl Nassib | LB | 18 | 13 | 1.5 | 0 | 0 | 1 |
| Desmond Trufant | CB | 17 | 14 | 0.0 | 0 | 6 | 0 |
| Amik Robertson | CB | 16 | 11 | 0.0 | 0 | 0 | 0 |
| Clelin Ferrell | DE | 14 | 8 | 1.5 | 0 | 1 | 0 |
| Roderic Teamer | DB | 14 | 9 | 0.0 | 0 | 1 | 0 |
| Keisean Nixon | CB | 11 | 6 | 0.0 | 0 | 0 | 0 |
| Marquel Lee | MLB | 10 | 5 | 0.0 | 0 | 0 | 0 |
| Tyree Gillespie | SAF | 8 | 1 | 0.0 | 0 | 0 | 0 |
| Damion Square | DT | 7 | 1 | 0.5 | 0 | 0 | 0 |
| Zay Jones | WR | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Foster Moreau | TE | 4 | 3 | 0.0 | 0 | 0 | 1 |
| Damon Arnette | CB | 4 | 2 | 0.0 | 0 | 1 | 0 |
| Alec Ingold | FB | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Malcolm Koonce | DE | 3 | 2 | 2.0 | 0 | 0 | 0 |
| Brandon Parker | OT | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Derek Carrier | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Hunter Renfrow | WR | 2 | 2 | 0.0 | 0 | 1 | 0 |
| DeSean Jackson | WR | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Tyron Johnson | WR | 2 | 2 | 0.0 | 0 | 0 | 1 |
| Darren Waller | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Carson Tinker | LS | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Will Compton | ILB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Daniel Helm | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Sutton Smith | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| AJ Cole | P | 1 | 1 | 0.0 | 0 | 0 | 1 |
| Trent Sieg | LS | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Bryan Edwards | WR | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Josh Jacobs | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dillon Stoner | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Alex Leatherwood | OT | 1 | 0 | 0.0 | 0 | 0 | 0 |