Franchise 57 seasons 446–445–6 all-time 20 playoff trips 3 Super Bowls
2023 players
Passing
| Aidan O'Connell | 343 | 213 | 2,218 | 12 | 7 | 6.5 |
| Jimmy Garoppolo | 169 | 110 | 1,205 | 7 | 9 | 7.1 |
| Brian Hoyer | 42 | 23 | 231 | 0 | 2 | 5.5 |
| Jakobi Meyers | 3 | 2 | 12 | 1 | 0 | 4.0 |
Rushing
| Josh Jacobs | 233 | 805 | 6 | 3.5 |
| Zamir White | 104 | 451 | 1 | 4.3 |
| Ameer Abdullah | 15 | 89 | 0 | 5.9 |
| Tre Tucker | 10 | 77 | 0 | 7.7 |
| Jimmy Garoppolo | 20 | 39 | 0 | 2.0 |
| Brandon Bolden | 4 | 31 | 1 | 7.8 |
| Jakobi Meyers | 4 | 24 | 2 | 6.0 |
| DeAndre Carter | 3 | 18 | 0 | 6.0 |
| Aidan O'Connell | 17 | 11 | 1 | 0.6 |
| Brian Hoyer | 3 | -3 | 0 | -1.0 |
Receiving
| Davante Adams | 175 | 103 | 1,144 | 8 | 6.5 |
| Jakobi Meyers | 106 | 71 | 807 | 8 | 7.6 |
| Tre Tucker | 34 | 19 | 331 | 2 | 9.7 |
| Michael Mayer | 40 | 27 | 304 | 2 | 7.6 |
| Josh Jacobs | 54 | 37 | 296 | 0 | 5.5 |
| Hunter Renfrow | 37 | 25 | 255 | 0 | 6.9 |
| Austin Hooper | 31 | 25 | 234 | 0 | 7.5 |
| Ameer Abdullah | 24 | 19 | 131 | 0 | 5.5 |
| Zamir White | 19 | 15 | 98 | 0 | 5.2 |
| DeAndre Carter | 7 | 4 | 39 | 0 | 5.6 |
| Jakob Johnson | 2 | 1 | 12 | 0 | 6.0 |
| Cole Fotheringham | 1 | 1 | 6 | 0 | 6.0 |
| Jesper Horsted | 1 | 1 | 4 | 0 | 4.0 |