Franchise 60 seasons 424–497–5 all-time 14 playoff trips 1 Super Bowls
2021 players
Passing
| Jameis Winston | 161 | 95 | 1,170 | 14 | 3 | 7.3 |
| Trevor Siemian | 188 | 108 | 1,154 | 11 | 3 | 6.1 |
| Taysom Hill | 134 | 78 | 978 | 4 | 5 | 7.3 |
| Ian Book | 20 | 12 | 135 | 0 | 2 | 6.8 |
| Blake Gillikin | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Alvin Kamara | 240 | 898 | 4 | 3.7 |
| Mark Ingram | 160 | 554 | 2 | 3.5 |
| Taysom Hill | 70 | 374 | 5 | 5.3 |
| Jameis Winston | 32 | 166 | 1 | 5.2 |
| Tony Jones | 54 | 142 | 0 | 2.6 |
| Ty Montgomery | 15 | 44 | 0 | 2.9 |
| Deonte Harty | 5 | 41 | 0 | 8.2 |
| Trevor Siemian | 9 | 20 | 1 | 2.2 |
| Dwayne Washington | 4 | 16 | 0 | 4.0 |
| Ian Book | 3 | 6 | 0 | 2.0 |
| Adam Prentice | 3 | 5 | 0 | 1.7 |
| Kenny Stills | 1 | 1 | 0 | 1.0 |
| Devine Ozigbo | 1 | -3 | 0 | -3.0 |
Receiving
| Marquez Callaway | 84 | 46 | 698 | 6 | 8.3 |
| Deonte Harty | 59 | 36 | 570 | 3 | 9.7 |
| Alvin Kamara | 67 | 47 | 439 | 5 | 6.6 |
| Tre'Quan Smith | 50 | 32 | 377 | 3 | 7.5 |
| Adam Trautman | 43 | 27 | 263 | 2 | 6.1 |
| Lil'Jordan Humphrey | 18 | 13 | 249 | 2 | 13.8 |
| Mark Ingram | 35 | 27 | 162 | 0 | 4.6 |
| Juwan Johnson | 22 | 13 | 159 | 4 | 7.2 |
| Nick Vannett | 15 | 9 | 133 | 1 | 8.9 |
| Ty Montgomery | 26 | 16 | 95 | 0 | 3.7 |
| Kenny Stills | 23 | 6 | 68 | 1 | 3.0 |
| Taysom Hill | 6 | 4 | 52 | 0 | 8.7 |
| Chris Hogan | 8 | 4 | 41 | 1 | 5.1 |
| Garrett Griffin | 4 | 4 | 39 | 0 | 9.8 |
| Kevin White | 5 | 1 | 38 | 0 | 7.6 |
| Tony Jones | 8 | 5 | 29 | 0 | 3.6 |
| Adam Prentice | 3 | 3 | 16 | 0 | 5.3 |
| Dwayne Washington | 2 | 2 | 12 | 0 | 6.0 |
| Ethan Wolf | 2 | 2 | 8 | 0 | 4.0 |
| Devine Ozigbo | 1 | 1 | 7 | 0 | 7.0 |
| Easop Winston | 1 | 1 | 5 | 0 | 5.0 |