Franchise 77 seasons 637–489–14 all-time 35 playoff trips 6 Super Bowls
2022 players
Passing
| Kenny Pickett | 389 | 245 | 2,404 | 7 | 9 | 6.2 |
| Mitchell Trubisky | 180 | 117 | 1,252 | 4 | 5 | 7.0 |
| Najee Harris | 1 | 1 | 4 | 0 | 0 | 4.0 |
Rushing
| Najee Harris | 272 | 1,034 | 7 | 3.8 |
| Jaylen Warren | 77 | 379 | 1 | 4.9 |
| Kenny Pickett | 55 | 237 | 3 | 4.3 |
| Benny Snell | 20 | 90 | 1 | 4.5 |
| Steven Sims | 13 | 70 | 0 | 5.4 |
| Gunner Olszewski | 8 | 39 | 0 | 4.9 |
| Mitchell Trubisky | 19 | 38 | 2 | 2.0 |
| Anthony McFarland | 6 | 30 | 0 | 5.0 |
| Connor Heyward | 2 | 27 | 0 | 13.5 |
| Diontae Johnson | 7 | 25 | 0 | 3.6 |
| George Pickens | 3 | 24 | 1 | 8.0 |
| Derek Watt | 9 | 21 | 1 | 2.3 |
| Marcus Allen | 1 | 4 | 0 | 4.0 |
Receiving
| Diontae Johnson | 147 | 86 | 882 | 0 | 6.0 |
| George Pickens | 84 | 52 | 801 | 4 | 9.5 |
| Pat Freiermuth | 98 | 63 | 732 | 2 | 7.5 |
| Najee Harris | 53 | 41 | 229 | 3 | 4.3 |
| Jaylen Warren | 33 | 28 | 214 | 0 | 6.5 |
| Connor Heyward | 17 | 12 | 151 | 1 | 8.9 |
| Zach Gentry | 23 | 19 | 132 | 0 | 5.7 |
| Steven Sims | 23 | 14 | 104 | 0 | 4.5 |
| Gunner Olszewski | 7 | 5 | 53 | 0 | 7.6 |
| Benny Snell | 2 | 2 | 17 | 0 | 8.5 |
| Derek Watt | 5 | 5 | 11 | 1 | 2.2 |
| Miles Boykin | 3 | 2 | 11 | 0 | 3.7 |
| Anthony McFarland | 2 | 2 | 11 | 0 | 5.5 |
| Cody White | 1 | 1 | 2 | 0 | 2.0 |