Franchise 51 seasons 420–381–1 all-time 21 playoff trips 2 Super Bowls
2023 players
Passing
| Geno Smith | 499 | 323 | 3,624 | 20 | 9 | 7.3 |
| Drew Lock | 76 | 48 | 543 | 3 | 3 | 7.1 |
Rushing
| Kenneth Walker III | 219 | 905 | 8 | 4.1 |
| Zach Charbonnet | 108 | 462 | 1 | 4.3 |
| Geno Smith | 37 | 155 | 1 | 4.2 |
| DeeJay Dallas | 10 | 36 | 0 | 3.6 |
| Drew Lock | 5 | 14 | 0 | 2.8 |
| Dee Eskridge | 2 | 5 | 0 | 2.5 |
| Jake Bobo | 1 | 3 | 1 | 3.0 |
Receiving
| DK Metcalf | 119 | 66 | 1,114 | 8 | 9.4 |
| Tyler Lockett | 122 | 79 | 894 | 5 | 7.3 |
| Jaxon Smith-Njigba | 93 | 63 | 628 | 4 | 6.8 |
| Noah Fant | 43 | 32 | 414 | 0 | 9.6 |
| Kenneth Walker III | 37 | 29 | 259 | 1 | 7.0 |
| Colby Parkinson | 34 | 25 | 247 | 2 | 7.3 |
| Zach Charbonnet | 40 | 33 | 209 | 0 | 5.2 |
| Jake Bobo | 25 | 19 | 196 | 2 | 7.8 |
| Will Dissly | 22 | 17 | 172 | 1 | 7.8 |
| DeeJay Dallas | 9 | 6 | 26 | 0 | 2.9 |
| Cody Thompson | 1 | 1 | 10 | 0 | 10.0 |
| Geno Smith | 1 | 1 | -2 | 0 | -2.0 |
Defense
| Bobby Wagner | MLB | 164 | 77 | 3.5 | 0 | 3 | 0 |
| Julian Love | SAF | 111 | 73 | 0.0 | 4 | 10 | 2 |
| Jordyn Brooks | LB | 101 | 52 | 4.5 | 1 | 4 | 1 |
| Quandre Diggs | S | 88 | 56 | 0.0 | 1 | 5 | 0 |
| Devon Witherspoon | CB | 71 | 48 | 3.0 | 1 | 16 | 1 |
| Leonard Williams | DE | 58 | 33 | 5.5 | 0 | 2 | 0 |
| Jarran Reed | DT | 51 | 24 | 7.0 | 0 | 2 | 1 |
| Boye Mafe | LB | 49 | 32 | 9.0 | 0 | 6 | 1 |
| Riq Woolen | CB | 49 | 38 | 0.0 | 2 | 11 | 0 |
| Jamal Adams | LB | 42 | 28 | 0.0 | 0 | 2 | 0 |
| Dre'Mont Jones | LB | 41 | 18 | 4.5 | 0 | 0 | 0 |
| Derick Hall | LB | 34 | 14 | 0.0 | 0 | 1 | 0 |
| Devin Bush | LB | 33 | 14 | 0.0 | 0 | 0 | 0 |
| Tre Brown | CB | 30 | 25 | 1.0 | 2 | 6 | 2 |
| Mike Jackson | CB | 28 | 22 | 0.0 | 0 | 5 | 0 |
| Darrell Taylor | DE | 26 | 15 | 5.5 | 0 | 1 | 1 |
| Artie Burns | CB | 21 | 11 | 0.0 | 0 | 2 | 0 |
| Mario Edwards | DT | 18 | 12 | 2.0 | 0 | 1 | 1 |
| Coby Bryant | SAF | 16 | 12 | 0.0 | 0 | 0 | 1 |
| Cameron Young | DT | 16 | 8 | 0.0 | 0 | 1 | 0 |
| Uchenna Nwosu | LB | 15 | 11 | 2.0 | 0 | 0 | 2 |
| Jon Rhattigan | LB | 14 | 8 | 0.0 | 0 | 0 | 0 |
| Nick Bellore | LB | 13 | 7 | 0.0 | 0 | 0 | 0 |
| Jerrick Reed II | SAF | 9 | 7 | 0.0 | 0 | 0 | 0 |
| Frank Clark | LB | 8 | 4 | 0.0 | 0 | 0 | 0 |
| Myles Adams | DT | 6 | 2 | 1.0 | 0 | 0 | 0 |
| Brady Russell | FB | 6 | 4 | 0.0 | 0 | 0 | 0 |
| Tyler Lockett | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| DeeJay Dallas | RB | 3 | 0 | 0.0 | 0 | 0 | 0 |
| Kelvin Joseph | CB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Mike Morris | DE | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Jake Bobo | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| DK Metcalf | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jaxon Smith-Njigba | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Drake Thomas | LB | 2 | 0 | 0.0 | 0 | 0 | 0 |
| Cody Thompson | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Dareke Young | WR | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Tyreke Smith | LB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Austin Faoliu | DT | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Kenneth Walker III | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Chris Stoll | LS | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Ty Okada | SAF | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Patrick O'Connell | LB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Zach Charbonnet | RB | 1 | 0 | 0.0 | 0 | 0 | 0 |