Franchise 51 seasons 326–471–1 all-time 15 playoff trips 2 Super Bowls
2007 players
Passing
| Jeff Garcia | 327 | 209 | 2,440 | 13 | 4 | 7.5 |
| Luke McCown | 139 | 94 | 1,009 | 5 | 3 | 7.3 |
| Bruce Gradkowski | 24 | 13 | 130 | 0 | 1 | 5.4 |
Rushing
| Earnest Graham | 222 | 898 | 10 | 4.0 |
| Michael Pittman | 69 | 288 | 0 | 4.2 |
| Michael Bennett | 60 | 239 | 1 | 4.0 |
| Cadillac Williams | 54 | 208 | 3 | 3.9 |
| Luke McCown | 12 | 117 | 0 | 9.8 |
| Jeff Garcia | 35 | 116 | 1 | 3.3 |
| Michael Clayton | 5 | 22 | 0 | 4.4 |
| Bruce Gradkowski | 7 | 20 | 0 | 2.9 |
| Kenneth Darby | 2 | 9 | 0 | 4.5 |
| Ike Hilliard | 1 | 6 | 0 | 6.0 |
| Joey Galloway | 1 | 1 | 0 | 1.0 |
| Zack Crockett | 1 | 0 | 0 | 0.0 |
Receiving
| Joey Galloway | 0 | 57 | 1,014 | 6 | 1014.0 |
| Ike Hilliard | 0 | 62 | 722 | 1 | 722.0 |
| Alex Smith | 1 | 32 | 385 | 3 | 385.0 |
| Earnest Graham | 0 | 49 | 324 | 0 | 324.0 |
| Michael Clayton | 0 | 22 | 301 | 0 | 301.0 |
| Michael Pittman | 0 | 26 | 191 | 0 | 191.0 |
| Jerramy Stevens | 0 | 18 | 189 | 4 | 189.0 |
| B.J. Askew | 0 | 18 | 175 | 0 | 175.0 |
| Michael Bennett | 0 | 15 | 99 | 1 | 99.0 |
| Maurice Stovall | 0 | 10 | 86 | 1 | 86.0 |
| Chad Lucas | 0 | 5 | 82 | 0 | 82.0 |
| Brian Clark | 0 | 4 | 23 | 0 | 23.0 |
| Anthony Becht | 0 | 5 | 20 | 2 | 20.0 |
| Cadillac Williams | 0 | 3 | 17 | 0 | 17.0 |
| Kenneth Darby | 0 | 2 | 16 | 0 | 16.0 |
| Byron Storer | 0 | 2 | 3 | 0 | 3.0 |
Defense
| Barrett Ruud | ILB | 92 | 61 | 0.0 | 2 | 3 | 4 |
| Derrick Brooks | OLB | 91 | 66 | 0.0 | 0 | 1 | 3 |
| Jermaine Phillips | FS | 80 | 67 | 1.0 | 4 | 7 | 3 |
| Cato June | LB | 57 | 36 | 0.0 | 1 | 4 | 1 |
| Phillip Buchanon | DB | 55 | 53 | 0.0 | 3 | 10 | 1 |
| Jovan Haye | DE | 54 | 34 | 6.0 | 0 | 3 | 1 |
| Tanard Jackson | DB | 52 | 49 | 0.0 | 2 | 13 | 1 |
| Ronde Barber | FS | 44 | 34 | 1.0 | 2 | 14 | 1 |
| Chris Hovan | DT | 38 | 21 | 1.5 | 1 | 2 | 0 |
| Gaines Adams | DE | 32 | 23 | 4.5 | 0 | 2 | 1 |
| Kevin Carter | DE | 32 | 21 | 3.0 | 0 | 1 | 0 |
| Quincy Black | OLB | 24 | 18 | 0.0 | 0 | 0 | 2 |
| Kalvin Pearson | FS | 20 | 18 | 0.0 | 0 | 0 | 0 |
| Stylez White | DE | 19 | 14 | 8.5 | 0 | 1 | 7 |
| Will Allen | S | 19 | 17 | 0.0 | 0 | 0 | 0 |
| Greg Spires | DE | 19 | 14 | 2.0 | 0 | 1 | 0 |
| Brian Kelly | CB | 18 | 16 | 0.0 | 2 | 7 | 0 |
| Ryan Sims | DE | 16 | 11 | 1.0 | 0 | 0 | 0 |
| Sammy Davis | DB | 15 | 12 | 0.0 | 0 | 1 | 0 |
| Greg Peterson | DT | 14 | 11 | 1.5 | 0 | 0 | 0 |
| Adam Hayward | OLB | 14 | 11 | 0.0 | 0 | 0 | 0 |
| Jeremiah Trotter | MLB | 13 | 9 | 0.0 | 0 | 0 | 0 |
| Maurice Stovall | WR | 11 | 10 | 0.0 | 0 | 0 | 0 |
| Ryan Nece | OLB | 11 | 11 | 0.0 | 0 | 0 | 0 |
| Patrick Chukwurah | LB | 8 | 7 | 1.0 | 0 | 0 | 0 |
| Torrie Cox | DB | 6 | 6 | 0.0 | 0 | 0 | 0 |
| Brian Clark | WR | 5 | 5 | 0.0 | 0 | 0 | 0 |
| Byron Storer | RB | 5 | 4 | 0.0 | 0 | 0 | 0 |
| B.J. Askew | FB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Earnest Graham | RB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Sabby Piscitelli | S | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Jerramy Stevens | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Micheal Spurlock | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Davin Joseph | G | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Ike Hilliard | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jeff Garcia | QB | 1 | 1 | 0.0 | 0 | 0 | 1 |
| Matt Lehr | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Michael Pittman | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Keith Heinrich | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Matt Bryant | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Michael Bennett | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Donald Penn | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jeremy Trueblood | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Kenneth Darby | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |