Franchise 77 seasons 536–586–17 all-time 20 playoff trips 3 Super Bowls
2018 players
Passing
| Alex Smith | 328 | 205 | 2,180 | 10 | 5 | 6.6 |
| Josh Johnson | 91 | 52 | 590 | 3 | 4 | 6.5 |
| Colt McCoy | 54 | 34 | 372 | 3 | 3 | 6.9 |
| Mark Sanchez | 35 | 19 | 138 | 0 | 3 | 3.9 |
| Tress Way | 1 | 1 | 7 | 0 | 0 | 7.0 |
Rushing
| Adrian Peterson | 251 | 1,042 | 7 | 4.2 |
| Chris Thompson | 43 | 178 | 0 | 4.1 |
| Alex Smith | 41 | 168 | 1 | 4.1 |
| Josh Johnson | 23 | 120 | 1 | 5.2 |
| Colt McCoy | 10 | 63 | 0 | 6.3 |
| Samaje Perine | 8 | 32 | 0 | 4.0 |
| Jamison Crowder | 4 | 30 | 0 | 7.5 |
| Maurice Harris | 2 | 10 | 0 | 5.0 |
| Byron Marshall | 3 | 9 | 0 | 3.0 |
| Paul Richardson | 2 | 9 | 0 | 4.5 |
| Mark Sanchez | 1 | 8 | 0 | 8.0 |
| Rob Kelley | 4 | 8 | 0 | 2.0 |
| Trey Quinn | 1 | 0 | 0 | 0.0 |
| Jehu Chesson | 1 | -4 | 0 | -4.0 |
Receiving
| Jordan Reed | 84 | 54 | 558 | 2 | 6.6 |
| Josh Doctson | 78 | 44 | 532 | 2 | 6.8 |
| Jamison Crowder | 49 | 29 | 388 | 2 | 7.9 |
| Vernon Davis | 36 | 25 | 367 | 2 | 10.2 |
| Maurice Harris | 47 | 28 | 304 | 0 | 6.5 |
| Chris Thompson | 55 | 41 | 268 | 1 | 4.9 |
| Paul Richardson | 35 | 20 | 262 | 2 | 7.5 |
| Adrian Peterson | 26 | 20 | 208 | 1 | 8.0 |
| Michael Floyd | 24 | 10 | 100 | 1 | 4.2 |
| Trey Quinn | 10 | 9 | 75 | 1 | 7.5 |
| Jeremy Sprinkle | 9 | 5 | 41 | 1 | 4.6 |
| Byron Marshall | 6 | 4 | 30 | 0 | 5.0 |
| Brian Quick | 3 | 3 | 18 | 0 | 6.0 |
| Matt Flanagan | 1 | 1 | 14 | 0 | 14.0 |
| Darvin Kidsy | 2 | 1 | 8 | 0 | 4.0 |
| Jehu Chesson | 2 | 1 | 7 | 0 | 3.5 |
| Samaje Perine | 4 | 3 | 5 | 0 | 1.2 |