Franchise 77 seasons 536–586–17 all-time 20 playoff trips 3 Super Bowls
2020 players
Passing
| Alex Smith | 252 | 168 | 1,582 | 6 | 8 | 6.3 |
| Dwayne Haskins | 241 | 148 | 1,439 | 5 | 7 | 6.0 |
| Kyle Allen | 87 | 60 | 610 | 4 | 1 | 7.0 |
| Taylor Heinicke | 19 | 12 | 137 | 1 | 0 | 7.2 |
| Logan Thomas | 1 | 1 | 28 | 0 | 0 | 28.0 |
| Isaiah Wright | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Antonio Gibson | 170 | 795 | 11 | 4.7 |
| J.D. McKissic | 85 | 365 | 1 | 4.3 |
| Peyton Barber | 94 | 258 | 4 | 2.7 |
| Dwayne Haskins | 20 | 46 | 1 | 2.3 |
| Terry McLaurin | 2 | 30 | 0 | 15.0 |
| Kyle Allen | 7 | 26 | 1 | 3.7 |
| Antonio Gandy-Golden | 1 | 22 | 0 | 22.0 |
| Taylor Heinicke | 3 | 22 | 0 | 7.3 |
| Steven Sims | 1 | 18 | 0 | 18.0 |
| Isaiah Wright | 3 | 16 | 0 | 5.3 |
| Logan Thomas | 3 | 5 | 0 | 1.7 |
| Cam Sims | 1 | 5 | 0 | 5.0 |
| Alex Smith | 10 | 3 | 0 | 0.3 |
Receiving
| Terry McLaurin | 134 | 87 | 1,118 | 4 | 8.3 |
| Logan Thomas | 110 | 72 | 670 | 6 | 6.1 |
| J.D. McKissic | 110 | 80 | 589 | 2 | 5.4 |
| Cam Sims | 48 | 32 | 477 | 1 | 9.9 |
| Steven Sims | 37 | 27 | 265 | 1 | 7.2 |
| Antonio Gibson | 44 | 36 | 247 | 0 | 5.6 |
| Isaiah Wright | 35 | 27 | 197 | 0 | 5.6 |
| Dontrelle Inman | 28 | 18 | 163 | 2 | 5.8 |
| Robert Foster | 6 | 2 | 37 | 0 | 6.2 |
| Peyton Barber | 7 | 4 | 12 | 0 | 1.7 |
| Temarrick Hemingway | 2 | 1 | 10 | 0 | 5.0 |
| Jeremy Sprinkle | 3 | 1 | 6 | 0 | 2.0 |
| Antonio Gandy-Golden | 7 | 1 | 3 | 0 | 0.4 |
| Marcus Baugh | 1 | 1 | 2 | 0 | 2.0 |