Franchise 77 seasons 536–586–17 all-time 20 playoff trips 3 Super Bowls
2021 players
Passing
| Taylor Heinicke | 494 | 321 | 3,419 | 20 | 15 | 6.9 |
| Garrett Gilbert | 31 | 20 | 194 | 0 | 0 | 6.3 |
| Kyle Allen | 19 | 12 | 120 | 1 | 0 | 6.3 |
| Ryan Fitzpatrick | 6 | 3 | 13 | 0 | 0 | 2.2 |
Rushing
| Antonio Gibson | 258 | 1,037 | 7 | 4.0 |
| Taylor Heinicke | 60 | 313 | 1 | 5.2 |
| Jaret Patterson | 68 | 266 | 2 | 3.9 |
| J.D. McKissic | 48 | 212 | 2 | 4.4 |
| DeAndre Carter | 10 | 89 | 0 | 8.9 |
| Jonathan Williams | 17 | 79 | 1 | 4.6 |
| Wendell Smallwood | 5 | 25 | 0 | 5.0 |
| Alex Armah | 5 | 21 | 0 | 4.2 |
| Terry McLaurin | 1 | 12 | 0 | 12.0 |
| Kyle Allen | 2 | 11 | 0 | 5.5 |
| Curtis Samuel | 4 | 11 | 0 | 2.8 |
| Cam Sims | 1 | 7 | 0 | 7.0 |
| Ryan Fitzpatrick | 1 | 2 | 0 | 2.0 |
| Dax Milne | 1 | 1 | 0 | 1.0 |
| Dyami Brown | 1 | -4 | 0 | -4.0 |
Receiving
| Terry McLaurin | 130 | 77 | 1,053 | 5 | 8.1 |
| J.D. McKissic | 53 | 43 | 397 | 2 | 7.5 |
| Adam Humphries | 62 | 41 | 383 | 0 | 6.2 |
| DeAndre Carter | 44 | 24 | 296 | 3 | 6.7 |
| Antonio Gibson | 52 | 42 | 294 | 3 | 5.7 |
| Ricky Seals-Jones | 49 | 30 | 271 | 2 | 5.5 |
| John Bates | 25 | 20 | 249 | 1 | 10.0 |
| Cam Sims | 23 | 15 | 211 | 2 | 9.2 |
| Logan Thomas | 25 | 18 | 196 | 3 | 7.8 |
| Dyami Brown | 25 | 12 | 165 | 0 | 6.6 |
| Dax Milne | 14 | 9 | 83 | 0 | 5.9 |
| Jaret Patterson | 11 | 10 | 73 | 0 | 6.6 |
| Jonathan Williams | 6 | 4 | 28 | 0 | 4.7 |
| Curtis Samuel | 9 | 6 | 27 | 0 | 3.0 |
| Wendell Smallwood | 5 | 4 | 22 | 0 | 4.4 |
| Alex Armah | 1 | 1 | 1 | 1 | 1.0 |
| Taylor Heinicke | 1 | 1 | -2 | 0 | -2.0 |
Defense
| Cole Holcomb | LB | 125 | 66 | 1.0 | 2 | 7 | 2 |
| Kam Curl | SAF | 94 | 57 | 1.0 | 0 | 5 | 0 |
| Landon Collins | LB | 76 | 46 | 3.0 | 2 | 2 | 1 |
| Kendall Fuller | CB | 71 | 58 | 1.0 | 1 | 16 | 0 |
| Jamin Davis | LB | 68 | 40 | 1.0 | 0 | 1 | 0 |
| Bobby McCain | CB | 62 | 46 | 0.0 | 4 | 9 | 0 |
| Jonathan Allen | DE | 55 | 24 | 9.0 | 0 | 0 | 0 |
| Daron Payne | NT | 54 | 28 | 4.5 | 0 | 0 | 0 |
| William Jackson | CB | 37 | 34 | 0.0 | 2 | 8 | 0 |
| Matthew Ioannidis | DT | 36 | 14 | 2.5 | 0 | 0 | 0 |
| James Smith-Williams | DE | 28 | 9 | 2.5 | 0 | 1 | 0 |
| David Mayo | OLB | 27 | 19 | 0.0 | 0 | 0 | 0 |
| Benjamin St-Juste | CB | 26 | 20 | 0.0 | 0 | 3 | 0 |
| Jeremy Reaves | SAF | 26 | 17 | 0.0 | 0 | 1 | 0 |
| Montez Sweat | DE | 23 | 12 | 5.0 | 0 | 0 | 3 |
| Casey Toohill | DE | 23 | 12 | 1.0 | 0 | 1 | 0 |
| Jon Bostic | ILB | 21 | 11 | 0.0 | 0 | 0 | 0 |
| Danny Johnson | DB | 21 | 15 | 0.0 | 0 | 2 | 1 |
| Chase Young | DE | 21 | 10 | 1.5 | 0 | 2 | 2 |
| Tim Settle | DT | 13 | 7 | 0.0 | 0 | 0 | 0 |
| Darryl Roberts | CB | 12 | 6 | 0.0 | 0 | 0 | 0 |
| Deshazor Everett | DB | 10 | 5 | 0.0 | 0 | 0 | 0 |
| Daniel Wise | DT | 10 | 5 | 0.0 | 0 | 0 | 0 |
| Bunmi Rotimi | DE | 9 | 4 | 1.0 | 0 | 0 | 0 |
| Khaleke Hudson | LB | 9 | 4 | 0.0 | 0 | 0 | 0 |
| Shaka Toney | DE | 8 | 2 | 1.5 | 0 | 0 | 0 |
| Darrick Forrest | SAF | 7 | 4 | 0.0 | 0 | 0 | 0 |
| Cam Sims | WR | 6 | 4 | 0.0 | 0 | 0 | 0 |
| Will Bradley-King | DE | 5 | 0 | 0.5 | 0 | 0 | 0 |
| Troy Apke | DB | 5 | 4 | 0.0 | 0 | 0 | 0 |
| Alex Armah | RB | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Jordan Kunaszyk | ILB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Terry McLaurin | WR | 4 | 4 | 0.0 | 0 | 0 | 0 |
| De'Jon Harris | LB | 3 | 3 | 1.0 | 0 | 0 | 0 |
| Corn Elder | CB | 3 | 3 | 0.0 | 0 | 1 | 0 |
| Jonathan Williams | RB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Tress Way | P | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Jared Norris | LB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Joey Slye | K | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Dyami Brown | WR | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Sammis Reyes | TE | 2 | 0 | 0.0 | 0 | 0 | 0 |
| DeAndre Carter | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Taylor Heinicke | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Akeem Spence | DT | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Cornelius Lucas | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Curtis Samuel | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| J.D. McKissic | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Adam Humphries | WR | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Brandon Scherff | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Torry McTyer | CB | 1 | 1 | 0.0 | 0 | 2 | 0 |
| Keith Ismael | C | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Antonio Gibson | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| John Bates | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |