49ers vs Colts Box Score, Week 16 2025

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San Francisco 49ers 48

Week 16 · 2025

Score by quarter
Team	1	2	3	4	T
SF	14	10	10	14	48
IND	7	10	3	7	27

27 Indianapolis Colts

Stars of the Game

QB · SF Brock Purdy 295 YDS • 5 TD • 1 INT

RB · SF Christian McCaffrey 117 YDS • 0 TD

WR · SF George Kittle 115 YDS • 7 REC • 1 TD

QB · IND Philip Rivers 277 YDS • 2 TD • 1 INT

RB · IND Jonathan Taylor 46 YDS • 1 TD

WR · IND Alec Pierce 86 YDS • 4 REC • 2 TD

Team Statistics

Score flow

Q1Q2Q3Q4

SFIND

Efficiency

IND

6.7 Yards / play 5.4

4.7 Yards / carry 2.9

8.7 Yards / attempt 7.7

25.4 EPA -2.1

20.5 Pass EPA -0.4

4.8 Rush EPA -1.8

Volume

IND

66 Plays 58

440 Total yards 312

295 Pass yards 277

145 Rush yards 58

28 First downs 19

Scoring

IND

5 Touchdowns 3

2 Field goals 2

1 Turnovers 2

Discipline

IND

2 Penalties 6

36 Penalty yards 45

Third down

SF 7/11 64%

IND 5/10 50%

Fourth down

SF 1/1 100%

IND 0/1 0%

Red zone

SF 4 TD · 2 FG 67%

IND 3 TD · 0 FG 100%

Touchdown Field goal No points

Time of possession

SF 33:05 IND 26:55

San Francisco 49ers at Indianapolis Colts, Week 16 2025