Regular season
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating | Drop% | BadTh% | OnTgt% | Press% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | PIT | 14 | 295 | 196 | 66.4 | 2621 | 17 | 11 | 30 | 8.9 | 98.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2005 | PIT | 12 | 268 | 168 | 62.7 | 2385 | 17 | 9 | 23 | 8.9 | 98.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2006 | PIT | 15 | 470 | 281 | 59.8 | 3528 | 18 | 23 | 46 | 7.5 | 75.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2007 | PIT | 15 | 405 | 265 | 65.4 | 3158 | 32 | 11 | 47 | 7.8 | 104.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2008 | PIT | 16 | 470 | 282 | 60.0 | 3314 | 17 | 15 | 47 | 7.1 | 80.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2009 | PIT | 15 | 506 | 337 | 66.6 | 4328 | 26 | 12 | 50 | 8.6 | 100.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2010 | PIT | 12 | 389 | 240 | 61.7 | 3200 | 17 | 5 | 32 | 8.2 | 97.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2011 | PIT | 15 | 513 | 324 | 63.2 | 4077 | 21 | 14 | 40 | 7.9 | 90.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2012 | PIT | 13 | 449 | 284 | 63.3 | 3265 | 26 | 8 | 30 | 7.3 | 97.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2013 | PIT | 16 | 584 | 375 | 64.2 | 4261 | 28 | 14 | 42 | 7.3 | 92.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2014 | PIT | 16 | 608 | 408 | 67.1 | 4952 | 32 | 9 | 33 | 8.1 | 103.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2015 | PIT | 12 | 469 | 319 | 68.0 | 3938 | 21 | 16 | 20 | 8.4 | 94.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2016 | PIT | 14 | 509 | 328 | 64.4 | 3819 | 29 | 13 | 17 | 7.5 | 95.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2017 | PIT | 15 | 562 | 361 | 64.2 | 4259 | 28 | 14 | 21 | 7.6 | 93.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2018 | PIT | 16 | 675 | 452 | 67.0 | 5129 | 34 | 16 | 24 | 7.6 | 96.5 | 3.6 | 18.3 | 0.0 | 16.7 | 2.3 |
| 2019 | PIT | 2 | 62 | 35 | 56.5 | 351 | 0 | 1 | 2 | 5.7 | 66.0 | 11.3 | 19.4 | 71.0 | 27.7 | 2.3 |
| 2020 | PIT | 15 | 608 | 399 | 65.6 | 3803 | 33 | 10 | 13 | 6.3 | 94.1 | 6.4 | 15.0 | 76.4 | 17.0 | 2.1 |
| 2021 | PIT | 16 | 605 | 390 | 64.5 | 3740 | 22 | 10 | 38 | 6.2 | 86.8 | 5.0 | 18.4 | 75.5 | 18.6 | 2.2 |