Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | PIT | 16 | 349 | 227 | 65.0 | 3028 | 20 | 16 | 32 | 8.7 | 92.4 |
| 2005 | PIT | 16 | 361 | 226 | 62.6 | 3188 | 24 | 12 | 29 | 8.8 | 99.4 |
| 2006 | PIT | 15 | 470 | 281 | 59.8 | 3528 | 18 | 23 | 46 | 7.5 | 75.6 |
| 2007 | PIT | 16 | 447 | 294 | 65.8 | 3495 | 34 | 14 | 53 | 7.8 | 101.8 |
| 2008 | PIT | 19 | 559 | 336 | 60.1 | 4006 | 20 | 16 | 54 | 7.2 | 82.0 |
| 2009 | PIT | 15 | 506 | 337 | 66.6 | 4328 | 26 | 12 | 50 | 8.6 | 100.5 |
| 2010 | PIT | 15 | 480 | 294 | 61.3 | 3822 | 21 | 9 | 41 | 8.0 | 93.1 |
| 2011 | PIT | 16 | 553 | 346 | 62.6 | 4366 | 22 | 15 | 45 | 7.9 | 89.1 |
| 2012 | PIT | 13 | 449 | 284 | 63.3 | 3265 | 26 | 8 | 30 | 7.3 | 97.0 |
| 2013 | PIT | 16 | 584 | 375 | 64.2 | 4261 | 28 | 14 | 42 | 7.3 | 92.0 |
| 2014 | PIT | 17 | 653 | 439 | 67.2 | 5286 | 33 | 11 | 38 | 8.1 | 101.7 |
| 2015 | PIT | 14 | 537 | 361 | 67.2 | 4506 | 22 | 16 | 26 | 8.4 | 94.3 |
| 2016 | PIT | 17 | 605 | 392 | 64.8 | 4554 | 32 | 17 | 19 | 7.5 | 93.4 |
| 2017 | PIT | 16 | 620 | 398 | 64.2 | 4728 | 33 | 15 | 23 | 7.6 | 95.0 |
| 2018 | PIT | 16 | 675 | 452 | 67.0 | 5129 | 34 | 16 | 24 | 7.6 | 96.5 |
| 2019 | PIT | 2 | 62 | 35 | 56.5 | 351 | 0 | 1 | 2 | 5.7 | 66.0 |
| 2020 | PIT | 16 | 676 | 446 | 66.0 | 4304 | 37 | 14 | 13 | 6.4 | 93.2 |
| 2021 | PIT | 17 | 649 | 419 | 64.6 | 3955 | 24 | 10 | 40 | 6.1 | 87.2 |