Regular season
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | CIN | 13 | 432 | 263 | 60.9 | 2897 | 18 | 18 | 25 | 6.7 | 77.3 |
| 2005 | CIN | 16 | 509 | 345 | 67.8 | 3836 | 32 | 12 | 20 | 7.5 | 101.1 |
| 2006 | CIN | 16 | 520 | 324 | 62.3 | 4036 | 28 | 13 | 36 | 7.8 | 93.9 |
| 2007 | CIN | 16 | 575 | 373 | 64.9 | 4130 | 26 | 20 | 17 | 7.2 | 86.6 |
| 2008 | CIN | 4 | 130 | 76 | 58.5 | 736 | 3 | 4 | 11 | 5.7 | 69.3 |
| 2009 | CIN | 16 | 466 | 282 | 60.5 | 3094 | 21 | 13 | 26 | 6.6 | 83.6 |
| 2010 | CIN | 16 | 586 | 362 | 61.8 | 3970 | 26 | 20 | 26 | 6.8 | 82.4 |
| 2011 | LV | 10 | 328 | 199 | 60.7 | 2753 | 13 | 16 | 17 | 8.4 | 80.5 |
| 2012 | LV | 15 | 565 | 345 | 61.1 | 4018 | 22 | 14 | 26 | 7.1 | 85.3 |
| 2013 | ARI | 16 | 572 | 362 | 63.3 | 4274 | 24 | 22 | 41 | 7.5 | 83.9 |
| 2014 | ARI | 6 | 224 | 141 | 62.9 | 1626 | 11 | 3 | 9 | 7.3 | 95.6 |
| 2015 | ARI | 16 | 537 | 342 | 63.7 | 4671 | 35 | 11 | 25 | 8.7 | 104.6 |
| 2016 | ARI | 15 | 597 | 364 | 61.0 | 4233 | 26 | 14 | 40 | 7.1 | 87.2 |
| 2017 | ARI | 7 | 267 | 164 | 61.4 | 1978 | 9 | 7 | 22 | 7.4 | 84.4 |