Regular season
| Year | Team | Games | Car | Rush Yds | Rush TD | 1st Down | Y/C | YBC/A | YAC/A | BT | BT% |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2005 | SF | 14 | 127 | 608 | 3 | 26 | 4.8 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2006 | SF | 16 | 313 | 1695 | 8 | 68 | 5.4 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2007 | SF | 15 | 260 | 1102 | 5 | 42 | 4.2 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2008 | SF | 14 | 240 | 1036 | 6 | 45 | 4.3 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2009 | SF | 14 | 229 | 1120 | 10 | 48 | 4.9 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2010 | SF | 11 | 203 | 853 | 3 | 44 | 4.2 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2011 | SF | 16 | 282 | 1211 | 8 | 57 | 4.3 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2012 | SF | 16 | 258 | 1214 | 8 | 67 | 4.7 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2013 | SF | 16 | 276 | 1128 | 9 | 57 | 4.1 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2014 | SF | 16 | 255 | 1106 | 4 | 57 | 4.3 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2015 | IND | 16 | 260 | 967 | 6 | 49 | 3.7 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2016 | IND | 16 | 263 | 1025 | 4 | 50 | 3.9 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2017 | IND | 16 | 261 | 961 | 3 | 50 | 3.7 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2018 | MIA | 14 | 156 | 722 | 0 | 25 | 4.6 | 2.3 | 2.4 | 11.0 | 7.1 |
| 2019 | BUF | 15 | 166 | 599 | 2 | 33 | 3.6 | 1.6 | 2.0 | 10.0 | 6.0 |
| 2020 | NYJ | 15 | 187 | 653 | 2 | 33 | 3.5 | 1.5 | 2.0 | 8.0 | 4.3 |