Regular season
| Year | Team | Games | Total Tkl | Solo | Ast | Sacks | TFL | QB Hits | INT | PD | FF | Def TD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2010 | IND | 4 | 3 | 3 | 0 | 0.0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 2011 | IND | 10 | 15 | 6 | 9 | 1.0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 2012 | IND | 15 | 41 | 29 | 12 | 4.0 | 7 | 10 | 0 | 1 | 0 | 0 |
| 2013 | BUF | 16 | 39 | 25 | 14 | 10.0 | 9 | 18 | 0 | 2 | 2 | 0 |
| 2014 | BUF | 15 | 43 | 26 | 17 | 10.0 | 12 | 20 | 0 | 0 | 3 | 0 |
| 2015 | BUF | 16 | 44 | 29 | 15 | 5.0 | 8 | 12 | 0 | 4 | 2 | 0 |
| 2016 | BUF | 16 | 39 | 22 | 17 | 6.0 | 7 | 11 | 0 | 3 | 1 | 0 |
| 2017 | BUF | 15 | 41 | 25 | 16 | 4.0 | 10 | 11 | 0 | 0 | 1 | 0 |
| 2018 | BUF | 15 | 29 | 22 | 7 | 7.0 | 9 | 18 | 0 | 1 | 3 | 0 |
| 2019 | BUF | 13 | 20 | 11 | 9 | 4.5 | 6 | 9 | 0 | 3 | 0 | 0 |
| 2020 | BUF | 14 | 26 | 16 | 10 | 4.5 | 3 | 11 | 1 | 3 | 2 | 0 |
| 2021 | BUF | 14 | 17 | 7 | 10 | 2.0 | 1 | 7 | 0 | 3 | 2 | 0 |
| 2022 | HOU | 16 | 33 | 19 | 14 | 9.0 | 10 | 10 | 1 | 1 | 2 | 0 |
| 2023 | HOU | 14 | 25 | 16 | 9 | 3.0 | 2 | 3 | 0 | 0 | 1 | 0 |
| 2024 | HOU | 4 | 4 | 2 | 2 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 |