Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2014 | NE | 5 | 27 | 19 | 70.4 | 182 | 1 | 0 | 5 | 6.7 | 101.2 |
| 2015 | NE | 4 | 4 | 1 | 25.0 | 6 | 0 | 0 | 0 | 1.5 | 39.6 |
| 2016 | NE | 6 | 63 | 43 | 68.3 | 502 | 4 | 0 | 3 | 8.0 | 113.3 |
| 2017 | SF | 6 | 178 | 120 | 67.4 | 1560 | 7 | 5 | 8 | 8.8 | 96.2 |
| 2018 | SF | 3 | 89 | 53 | 59.6 | 718 | 5 | 3 | 13 | 8.1 | 90.0 |
| 2019 | SF | 19 | 534 | 366 | 68.5 | 4405 | 29 | 16 | 40 | 8.2 | 99.2 |
| 2020 | SF | 6 | 140 | 94 | 67.1 | 1096 | 7 | 5 | 11 | 7.8 | 92.4 |
| 2021 | SF | 18 | 515 | 344 | 66.8 | 4345 | 22 | 15 | 33 | 8.4 | 95.0 |
| 2022 | SF | 11 | 308 | 207 | 67.2 | 2437 | 16 | 4 | 18 | 7.9 | 103.0 |
| 2023 | LV | 7 | 169 | 110 | 65.1 | 1205 | 7 | 9 | 14 | 7.1 | 77.7 |
| 2024 | LA | 1 | 41 | 27 | 65.9 | 334 | 2 | 1 | 3 | 8.1 | 97.0 |