Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2018 | BUF | 12 | 319 | 168 | 52.7 | 2044 | 10 | 12 | 28 | 6.4 | 67.4 |
| 2019 | BUF | 17 | 507 | 295 | 58.2 | 3353 | 20 | 9 | 41 | 6.6 | 83.9 |
| 2020 | BUF | 19 | 692 | 473 | 68.4 | 5361 | 42 | 11 | 34 | 7.7 | 104.9 |
| 2021 | BUF | 19 | 708 | 457 | 64.5 | 5044 | 45 | 15 | 28 | 7.1 | 97.9 |
| 2022 | BUF | 18 | 648 | 407 | 62.8 | 4899 | 38 | 17 | 41 | 7.6 | 94.5 |
| 2023 | BUF | 19 | 648 | 432 | 66.7 | 4695 | 33 | 18 | 26 | 7.2 | 93.2 |
| 2024 | BUF | 19 | 565 | 365 | 64.6 | 4367 | 32 | 6 | 19 | 7.7 | 102.6 |
| 2025 | BUF | 18 | 534 | 372 | 69.7 | 4224 | 29 | 12 | 44 | 7.9 | 101.8 |
| 2026 | BUF | 6 | 171 | 114 | 66.7 | 1504 | 9 | 4 | 12 | 8.8 | 102.1 |