Regular season
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2005 | CHI | 15 | 368 | 190 | 51.6 | 1869 | 9 | 13 | 30 | 5.1 | 59.7 |
| 2007 | CHI | 3 | 79 | 42 | 53.2 | 475 | 3 | 2 | 2 | 6.0 | 73.5 |
| 2008 | CHI | 15 | 466 | 273 | 58.6 | 2979 | 18 | 12 | 27 | 6.4 | 79.7 |
| 2009 | DEN | 16 | 541 | 336 | 62.1 | 3802 | 21 | 12 | 29 | 7.0 | 86.8 |
| 2010 | DEN | 13 | 498 | 293 | 58.8 | 3652 | 20 | 9 | 34 | 7.3 | 87.5 |
| 2011 | KC | 9 | 252 | 150 | 59.5 | 1758 | 9 | 9 | 10 | 7.0 | 77.8 |
| 2012 | DAL | 1 | 10 | 9 | 90.0 | 89 | 1 | 0 | 0 | 8.9 | 137.1 |
| 2013 | DAL | 2 | 51 | 33 | 64.7 | 398 | 2 | 2 | 0 | 7.8 | 85.3 |
| 2014 | BUF | 12 | 447 | 287 | 64.2 | 3018 | 18 | 10 | 33 | 6.8 | 87.8 |