Regular season
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1999 | GB | 16 | 10 | 3 | 30.0 | 41 | 1 | 0 | 1 | 4.1 | 77.5 |
| 2000 | GB | 4 | 19 | 10 | 52.6 | 104 | 1 | 0 | 1 | 5.5 | 86.3 |
| 2001 | SEA | 13 | 321 | 176 | 54.8 | 2023 | 7 | 8 | 38 | 6.3 | 70.9 |
| 2002 | SEA | 13 | 419 | 267 | 63.7 | 3075 | 15 | 10 | 26 | 7.3 | 87.8 |
| 2003 | SEA | 16 | 513 | 313 | 61.0 | 3844 | 26 | 15 | 42 | 7.5 | 88.9 |
| 2004 | SEA | 14 | 474 | 279 | 58.9 | 3390 | 22 | 15 | 29 | 7.2 | 83.2 |
| 2005 | SEA | 16 | 450 | 294 | 65.3 | 3455 | 24 | 10 | 23 | 7.7 | 97.0 |
| 2006 | SEA | 12 | 371 | 210 | 56.6 | 2442 | 18 | 15 | 34 | 6.6 | 76.0 |
| 2007 | SEA | 16 | 562 | 352 | 62.6 | 3966 | 28 | 12 | 33 | 7.1 | 91.4 |
| 2008 | SEA | 7 | 209 | 109 | 52.2 | 1216 | 5 | 10 | 19 | 5.8 | 57.8 |
| 2009 | SEA | 14 | 488 | 293 | 60.0 | 3029 | 17 | 17 | 32 | 6.2 | 75.1 |
| 2010 | SEA | 14 | 444 | 266 | 59.9 | 2998 | 12 | 17 | 29 | 6.8 | 73.2 |
| 2011 | TEN | 16 | 518 | 319 | 61.6 | 3571 | 18 | 14 | 19 | 6.9 | 82.4 |
| 2012 | TEN | 8 | 221 | 138 | 62.4 | 1367 | 7 | 5 | 14 | 6.2 | 81.0 |
| 2013 | IND | 3 | 12 | 7 | 58.3 | 130 | 0 | 1 | 0 | 10.8 | 61.1 |
| 2014 | IND | 4 | 44 | 30 | 68.2 | 301 | 2 | 0 | 2 | 6.8 | 102.6 |
| 2015 | IND | 8 | 256 | 156 | 60.9 | 1690 | 9 | 5 | 16 | 6.6 | 84.0 |