Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2009 | DET | 10 | 377 | 201 | 53.3 | 2267 | 13 | 20 | 23 | 6.0 | 61.0 |
| 2010 | DET | 3 | 96 | 57 | 59.4 | 535 | 6 | 1 | 4 | 5.6 | 91.3 |
| 2011 | DET | 17 | 716 | 456 | 63.7 | 5480 | 44 | 18 | 38 | 7.7 | 97.1 |
| 2012 | DET | 16 | 727 | 435 | 59.8 | 4967 | 20 | 17 | 29 | 6.8 | 79.8 |
| 2013 | DET | 16 | 634 | 371 | 58.5 | 4650 | 29 | 19 | 23 | 7.3 | 84.2 |
| 2014 | DET | 17 | 644 | 391 | 60.7 | 4580 | 23 | 13 | 48 | 7.1 | 85.8 |
| 2015 | DET | 16 | 592 | 398 | 67.2 | 4262 | 32 | 13 | 44 | 7.2 | 97.0 |
| 2016 | DET | 17 | 626 | 406 | 64.9 | 4532 | 24 | 10 | 40 | 7.2 | 92.4 |
| 2017 | DET | 16 | 565 | 371 | 65.7 | 4446 | 29 | 10 | 47 | 7.9 | 99.3 |
| 2018 | DET | 16 | 555 | 367 | 66.1 | 3777 | 21 | 11 | 40 | 6.8 | 89.9 |
| 2019 | DET | 8 | 291 | 187 | 64.3 | 2499 | 19 | 5 | 18 | 8.6 | 106.0 |
| 2020 | DET | 16 | 528 | 339 | 64.2 | 4084 | 26 | 10 | 38 | 7.7 | 96.3 |
| 2021 | LA | 21 | 741 | 502 | 67.7 | 6074 | 50 | 20 | 37 | 8.2 | 103.9 |
| 2022 | LA | 9 | 303 | 206 | 68.0 | 2087 | 10 | 8 | 29 | 6.9 | 87.4 |
| 2023 | LA | 16 | 557 | 351 | 63.0 | 4332 | 26 | 11 | 32 | 7.8 | 94.3 |
| 2024 | LA | 18 | 588 | 385 | 65.5 | 4295 | 24 | 8 | 35 | 7.3 | 95.0 |
| 2025 | LA | 20 | 716 | 454 | 63.4 | 5643 | 52 | 9 | 29 | 7.9 | 106.7 |
| 2026 | LA | 7 | 278 | 187 | 67.3 | 1989 | 14 | 7 | 11 | 7.2 | 94.2 |