Regular season
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating | Drop% | BadTh% | OnTgt% | Press% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2017 | CHI | 12 | 330 | 196 | 59.4 | 2193 | 7 | 7 | 31 | 6.6 | 77.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2018 | CHI | 14 | 434 | 289 | 66.6 | 3223 | 24 | 12 | 24 | 7.4 | 95.4 | 2.6 | 18.4 | 0.0 | 20.4 | 2.4 |
| 2019 | CHI | 15 | 516 | 326 | 63.2 | 3138 | 17 | 10 | 38 | 6.1 | 83.0 | 5.5 | 18.4 | 74.5 | 21.9 | 2.3 |
| 2020 | CHI | 10 | 297 | 199 | 67.0 | 2055 | 16 | 8 | 18 | 6.9 | 93.5 | 3.1 | 18.1 | 75.8 | 19.3 | 2.3 |
| 2021 | BUF | 5 | 8 | 6 | 75.0 | 43 | 0 | 1 | 0 | 5.4 | 47.4 | 12.5 | 12.5 | 87.5 | 0.0 | 2.2 |
| 2022 | PIT | 7 | 180 | 117 | 65.0 | 1252 | 4 | 5 | 11 | 7.0 | 81.1 | 4.0 | 14.1 | 73.4 | 15.4 | 2.3 |
| 2023 | PIT | 5 | 107 | 67 | 62.6 | 632 | 4 | 5 | 7 | 5.9 | 71.9 | 4.8 | 19.0 | 78.1 | 17.2 | 2.4 |
| 2024 | BUF | 8 | 26 | 19 | 73.1 | 179 | 2 | 0 | 0 | 6.9 | 117.3 | 0.0 | 16.0 | 84.0 | 11.1 | 2.2 |
| 2025 | BUF | 4 | 35 | 25 | 71.4 | 313 | 4 | 0 | 0 | 8.9 | 137.0 | 8.8 | 11.8 | 85.3 | 0.0 | 2.6 |