Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2017 | CHI | 12 | 330 | 196 | 59.4 | 2193 | 7 | 7 | 31 | 6.6 | 77.5 |
| 2018 | CHI | 15 | 477 | 315 | 66.0 | 3526 | 25 | 12 | 26 | 7.4 | 94.9 |
| 2019 | CHI | 15 | 516 | 326 | 63.2 | 3138 | 17 | 10 | 38 | 6.1 | 83.0 |
| 2020 | CHI | 11 | 326 | 218 | 66.9 | 2254 | 17 | 8 | 19 | 6.9 | 93.8 |
| 2021 | BUF | 6 | 8 | 6 | 75.0 | 43 | 0 | 1 | 0 | 5.4 | 47.4 |
| 2022 | PIT | 7 | 180 | 117 | 65.0 | 1252 | 4 | 5 | 11 | 7.0 | 81.1 |
| 2023 | PIT | 5 | 107 | 67 | 62.6 | 632 | 4 | 5 | 7 | 5.9 | 71.9 |
| 2024 | BUF | 9 | 26 | 19 | 73.1 | 179 | 2 | 0 | 0 | 6.9 | 117.3 |
| 2025 | BUF | 4 | 35 | 25 | 71.4 | 313 | 4 | 0 | 0 | 8.9 | 137.0 |