Regular season
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1998 | IND | 16 | 575 | 326 | 56.7 | 3739 | 26 | 28 | 22 | 6.5 | 71.2 |
| 1999 | IND | 16 | 533 | 331 | 62.1 | 4135 | 26 | 15 | 14 | 7.8 | 90.7 |
| 2000 | IND | 16 | 571 | 357 | 62.5 | 4413 | 33 | 15 | 20 | 7.7 | 94.7 |
| 2001 | IND | 16 | 547 | 343 | 62.7 | 4131 | 26 | 23 | 29 | 7.6 | 84.1 |
| 2002 | IND | 16 | 591 | 392 | 66.3 | 4200 | 27 | 19 | 23 | 7.1 | 88.8 |
| 2003 | IND | 16 | 566 | 379 | 67.0 | 4267 | 29 | 10 | 19 | 7.5 | 99.0 |
| 2004 | IND | 16 | 497 | 336 | 67.6 | 4557 | 49 | 10 | 13 | 9.2 | 121.1 |
| 2005 | IND | 16 | 453 | 305 | 67.3 | 3747 | 28 | 10 | 17 | 8.3 | 104.1 |
| 2006 | IND | 16 | 557 | 362 | 65.0 | 4397 | 31 | 9 | 14 | 7.9 | 101.0 |
| 2007 | IND | 16 | 515 | 337 | 65.4 | 4040 | 31 | 14 | 21 | 7.8 | 98.0 |
| 2008 | IND | 16 | 555 | 371 | 66.8 | 4002 | 27 | 12 | 14 | 7.2 | 95.0 |
| 2009 | IND | 16 | 571 | 393 | 68.8 | 4500 | 33 | 16 | 10 | 7.9 | 99.9 |
| 2010 | IND | 16 | 679 | 450 | 66.3 | 4700 | 33 | 17 | 16 | 6.9 | 91.9 |
| 2012 | DEN | 16 | 583 | 400 | 68.6 | 4659 | 37 | 11 | 21 | 8.0 | 105.8 |
| 2013 | DEN | 16 | 659 | 450 | 68.3 | 5477 | 55 | 10 | 18 | 8.3 | 115.1 |
| 2014 | DEN | 16 | 597 | 395 | 66.2 | 4727 | 39 | 15 | 17 | 7.9 | 101.5 |
| 2015 | DEN | 10 | 331 | 198 | 59.8 | 2249 | 9 | 17 | 16 | 6.8 | 67.9 |