Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1998 | IND | 16 | 575 | 326 | 56.7 | 3739 | 26 | 28 | 22 | 6.5 | 71.2 |
| 1999 | IND | 16 | 533 | 331 | 62.1 | 4135 | 26 | 15 | 14 | 7.8 | 90.7 |
| 2000 | IND | 17 | 603 | 374 | 62.0 | 4607 | 34 | 15 | 20 | 7.6 | 94.0 |
| 2001 | IND | 16 | 547 | 343 | 62.7 | 4131 | 26 | 23 | 29 | 7.6 | 84.1 |
| 2002 | IND | 17 | 622 | 406 | 65.3 | 4337 | 27 | 21 | 24 | 7.0 | 85.9 |
| 2003 | IND | 19 | 669 | 446 | 66.7 | 5185 | 38 | 14 | 24 | 7.8 | 100.1 |
| 2004 | IND | 18 | 572 | 390 | 68.2 | 5252 | 53 | 12 | 15 | 9.2 | 119.3 |
| 2005 | IND | 17 | 491 | 327 | 66.6 | 4037 | 29 | 10 | 22 | 8.2 | 103.0 |
| 2006 | IND | 20 | 710 | 459 | 64.6 | 5431 | 34 | 16 | 20 | 7.6 | 94.4 |
| 2007 | IND | 17 | 563 | 370 | 65.7 | 4442 | 34 | 16 | 21 | 7.9 | 98.0 |
| 2008 | IND | 17 | 597 | 396 | 66.3 | 4312 | 28 | 12 | 15 | 7.2 | 94.7 |
| 2009 | IND | 19 | 699 | 480 | 68.7 | 5456 | 39 | 18 | 14 | 7.8 | 99.7 |
| 2010 | IND | 17 | 705 | 468 | 66.4 | 4925 | 34 | 17 | 17 | 7.0 | 92.5 |
| 2012 | DEN | 17 | 626 | 428 | 68.4 | 4949 | 40 | 13 | 24 | 7.9 | 104.6 |
| 2013 | DEN | 19 | 787 | 541 | 68.7 | 6387 | 60 | 13 | 19 | 8.1 | 111.7 |
| 2014 | DEN | 17 | 643 | 421 | 65.5 | 4938 | 40 | 15 | 19 | 7.7 | 99.7 |
| 2015 | DEN | 13 | 423 | 249 | 58.9 | 2788 | 11 | 18 | 25 | 6.6 | 69.5 |