Regular season
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating | Drop% | BadTh% | OnTgt% | Press% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | LAC | 2 | 8 | 5 | 62.5 | 33 | 1 | 0 | 0 | 4.1 | 110.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2005 | LAC | 2 | 22 | 12 | 54.5 | 115 | 0 | 1 | 3 | 5.2 | 50.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2006 | LAC | 16 | 460 | 284 | 61.7 | 3387 | 22 | 9 | 28 | 7.4 | 92.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2007 | LAC | 16 | 460 | 277 | 60.2 | 3152 | 21 | 15 | 22 | 6.9 | 82.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2008 | LAC | 16 | 478 | 312 | 65.3 | 4004 | 34 | 11 | 25 | 8.4 | 105.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2009 | LAC | 16 | 486 | 317 | 65.2 | 4254 | 28 | 9 | 25 | 8.8 | 104.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2010 | LAC | 16 | 541 | 357 | 66.0 | 4710 | 30 | 13 | 38 | 8.7 | 101.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2011 | LAC | 16 | 582 | 366 | 62.9 | 4624 | 27 | 20 | 30 | 7.9 | 88.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2012 | LAC | 16 | 527 | 338 | 64.1 | 3606 | 26 | 15 | 49 | 6.8 | 88.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2013 | LAC | 16 | 544 | 378 | 69.5 | 4478 | 32 | 11 | 30 | 8.2 | 105.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2014 | LAC | 16 | 570 | 379 | 66.5 | 4286 | 31 | 18 | 36 | 7.5 | 93.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2015 | LAC | 16 | 661 | 437 | 66.1 | 4792 | 29 | 13 | 40 | 7.2 | 93.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2016 | LAC | 16 | 578 | 349 | 60.4 | 4386 | 33 | 21 | 36 | 7.6 | 87.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2017 | LAC | 16 | 575 | 360 | 62.6 | 4515 | 28 | 10 | 18 | 7.9 | 96.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2018 | LAC | 16 | 508 | 347 | 68.3 | 4308 | 32 | 12 | 32 | 8.5 | 105.5 | 4.6 | 12.9 | 0.0 | 22.6 | 2.4 |
| 2019 | LAC | 16 | 591 | 390 | 66.0 | 4615 | 23 | 20 | 34 | 7.8 | 88.5 | 4.4 | 15.4 | 76.7 | 20.6 | 2.5 |
| 2020 | IND | 16 | 543 | 369 | 68.0 | 4169 | 24 | 11 | 19 | 7.7 | 97.0 | 3.2 | 16.0 | 77.2 | 16.5 | 2.3 |
| 2025 | IND | 3 | 92 | 58 | 63.0 | 544 | 4 | 3 | 5 | 5.9 | 80.2 | 2.2 | 14.4 | 71.1 | 18.6 | 2.1 |