Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | LAC | 2 | 8 | 5 | 62.5 | 33 | 1 | 0 | 0 | 4.1 | 110.9 |
| 2005 | LAC | 2 | 22 | 12 | 54.5 | 115 | 0 | 1 | 3 | 5.2 | 50.4 |
| 2006 | LAC | 17 | 492 | 298 | 60.6 | 3617 | 22 | 10 | 31 | 7.4 | 89.6 |
| 2007 | LAC | 19 | 546 | 329 | 60.3 | 3919 | 25 | 19 | 24 | 7.2 | 83.0 |
| 2008 | LAC | 18 | 549 | 353 | 64.3 | 4529 | 37 | 13 | 33 | 8.2 | 102.6 |
| 2009 | LAC | 17 | 526 | 344 | 65.4 | 4552 | 29 | 11 | 27 | 8.7 | 102.3 |
| 2010 | LAC | 16 | 541 | 357 | 66.0 | 4710 | 30 | 13 | 38 | 8.7 | 101.8 |
| 2011 | LAC | 16 | 582 | 366 | 62.9 | 4624 | 27 | 20 | 30 | 7.9 | 88.7 |
| 2012 | LAC | 16 | 527 | 338 | 64.1 | 3606 | 26 | 15 | 49 | 6.8 | 88.6 |
| 2013 | LAC | 18 | 587 | 408 | 69.5 | 4823 | 35 | 11 | 35 | 8.2 | 106.3 |
| 2014 | LAC | 16 | 570 | 379 | 66.5 | 4286 | 31 | 18 | 36 | 7.5 | 93.8 |
| 2015 | LAC | 16 | 661 | 437 | 66.1 | 4792 | 29 | 13 | 40 | 7.2 | 93.8 |
| 2016 | LAC | 16 | 578 | 349 | 60.4 | 4386 | 33 | 21 | 36 | 7.6 | 87.9 |
| 2017 | LAC | 16 | 575 | 360 | 62.6 | 4515 | 28 | 10 | 18 | 7.9 | 96.0 |
| 2018 | LAC | 18 | 591 | 394 | 66.7 | 4799 | 35 | 13 | 35 | 8.1 | 102.0 |
| 2019 | LAC | 16 | 591 | 390 | 66.0 | 4615 | 23 | 20 | 34 | 7.8 | 88.5 |
| 2020 | IND | 17 | 589 | 396 | 67.2 | 4478 | 26 | 11 | 19 | 7.6 | 96.7 |
| 2025 | IND | 3 | 92 | 58 | 63.0 | 544 | 4 | 3 | 5 | 5.9 | 80.2 |