Regular season
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating | Drop% | BadTh% | OnTgt% | Press% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2012 | SEA | 16 | 393 | 252 | 64.1 | 3118 | 26 | 10 | 33 | 7.9 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2013 | SEA | 16 | 407 | 257 | 63.1 | 3357 | 26 | 9 | 44 | 8.2 | 101.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2014 | SEA | 16 | 452 | 285 | 63.1 | 3475 | 20 | 7 | 42 | 7.7 | 95.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2015 | SEA | 16 | 483 | 329 | 68.1 | 4024 | 34 | 8 | 45 | 8.3 | 110.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2016 | SEA | 16 | 546 | 353 | 64.7 | 4219 | 21 | 11 | 41 | 7.7 | 92.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2017 | SEA | 16 | 553 | 339 | 61.3 | 3983 | 34 | 11 | 43 | 7.2 | 95.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2018 | SEA | 16 | 427 | 280 | 65.6 | 3448 | 35 | 7 | 51 | 8.1 | 110.9 | 4.6 | 15.4 | 0.0 | 32.3 | 2.5 |
| 2019 | SEA | 16 | 516 | 341 | 66.1 | 4110 | 31 | 5 | 48 | 8.0 | 106.3 | 3.4 | 18.5 | 76.3 | 28.9 | 2.5 |
| 2020 | SEA | 16 | 558 | 384 | 68.8 | 4212 | 40 | 13 | 47 | 7.5 | 105.1 | 5.1 | 15.8 | 79.5 | 27.2 | 2.6 |
| 2021 | SEA | 14 | 400 | 259 | 64.8 | 3113 | 25 | 6 | 33 | 7.8 | 103.1 | 4.1 | 18.6 | 76.5 | 27.0 | 2.4 |
| 2022 | DEN | 15 | 483 | 292 | 60.5 | 3524 | 16 | 11 | 55 | 7.3 | 84.4 | 6.7 | 15.6 | 73.3 | 28.6 | 2.5 |
| 2023 | DEN | 15 | 447 | 297 | 66.4 | 3070 | 26 | 8 | 45 | 6.9 | 98.0 | 4.1 | 13.2 | 77.9 | 25.5 | 2.7 |
| 2024 | PIT | 11 | 336 | 214 | 63.7 | 2482 | 16 | 5 | 33 | 7.4 | 95.6 | 4.5 | 16.8 | 76.4 | 26.9 | 2.4 |
| 2025 | NYG | 6 | 119 | 69 | 58.0 | 831 | 3 | 3 | 10 | 7.0 | 77.4 | 3.7 | 20.6 | 70.1 | 25.5 | 2.3 |