Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2012 | SEA | 18 | 455 | 291 | 64.0 | 3690 | 29 | 11 | 40 | 8.1 | 100.3 |
| 2013 | SEA | 19 | 475 | 300 | 63.2 | 3881 | 29 | 9 | 51 | 8.2 | 101.2 |
| 2014 | SEA | 19 | 524 | 326 | 62.2 | 4199 | 26 | 12 | 52 | 8.0 | 94.3 |
| 2015 | SEA | 18 | 557 | 373 | 67.0 | 4532 | 38 | 11 | 52 | 8.1 | 106.3 |
| 2016 | SEA | 18 | 606 | 393 | 64.9 | 4668 | 25 | 13 | 47 | 7.7 | 93.0 |
| 2017 | SEA | 16 | 553 | 339 | 61.3 | 3983 | 34 | 11 | 43 | 7.2 | 95.4 |
| 2018 | SEA | 17 | 454 | 298 | 65.6 | 3681 | 36 | 7 | 52 | 8.1 | 110.6 |
| 2019 | SEA | 18 | 577 | 380 | 65.9 | 4712 | 33 | 5 | 54 | 8.2 | 106.4 |
| 2020 | SEA | 17 | 585 | 395 | 67.5 | 4386 | 42 | 14 | 52 | 7.5 | 103.6 |
| 2021 | SEA | 14 | 400 | 259 | 64.8 | 3113 | 25 | 6 | 33 | 7.8 | 103.1 |
| 2022 | DEN | 15 | 483 | 292 | 60.5 | 3524 | 16 | 11 | 55 | 7.3 | 84.4 |
| 2023 | DEN | 15 | 447 | 297 | 66.4 | 3070 | 26 | 8 | 45 | 6.9 | 98.0 |
| 2024 | PIT | 12 | 365 | 234 | 64.1 | 2752 | 18 | 5 | 37 | 7.5 | 97.7 |
| 2025 | NYG | 6 | 119 | 69 | 58.0 | 831 | 3 | 3 | 10 | 7.0 | 77.4 |