Regular season
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating | Drop% | BadTh% | OnTgt% | Press% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2005 | LA | 4 | 135 | 76 | 56.3 | 777 | 4 | 8 | 9 | 5.8 | 58.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2008 | CIN | 12 | 372 | 221 | 59.4 | 1905 | 8 | 9 | 38 | 5.1 | 70.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2009 | BUF | 10 | 227 | 127 | 55.9 | 1422 | 9 | 10 | 22 | 6.3 | 69.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2010 | BUF | 13 | 441 | 255 | 57.8 | 2992 | 23 | 15 | 24 | 6.8 | 81.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2011 | BUF | 16 | 569 | 353 | 62.0 | 3832 | 24 | 23 | 22 | 6.7 | 79.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2012 | BUF | 16 | 505 | 306 | 60.6 | 3400 | 24 | 16 | 30 | 6.7 | 83.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2013 | TEN | 11 | 350 | 217 | 62.0 | 2454 | 14 | 12 | 21 | 7.0 | 82.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2014 | HOU | 12 | 312 | 197 | 63.1 | 2483 | 17 | 8 | 21 | 8.0 | 95.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2015 | NYJ | 16 | 562 | 335 | 59.6 | 3905 | 31 | 15 | 19 | 6.9 | 88.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2016 | NYJ | 14 | 403 | 228 | 56.6 | 2710 | 12 | 17 | 19 | 6.7 | 69.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2017 | TB | 6 | 163 | 96 | 58.9 | 1103 | 7 | 3 | 7 | 6.8 | 86.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 2018 | TB | 8 | 246 | 164 | 66.7 | 2366 | 17 | 12 | 14 | 9.6 | 100.4 | 3.3 | 15.0 | 0.0 | 23.0 | 2.4 |
| 2019 | MIA | 15 | 502 | 311 | 62.0 | 3529 | 20 | 13 | 40 | 7.0 | 85.5 | 5.7 | 17.7 | 72.8 | 26.7 | 2.3 |
| 2020 | MIA | 9 | 267 | 183 | 68.5 | 2091 | 13 | 8 | 14 | 7.8 | 95.6 | 3.8 | 14.0 | 79.9 | 22.6 | 2.2 |
| 2021 | WAS | 1 | 6 | 3 | 50.0 | 13 | 0 | 0 | 1 | 2.2 | 56.2 | 16.7 | 16.7 | 83.3 | 50.0 | 1.8 |