Regular season and playoffs
| Year | Team | Games | Att | Cmp | Cmp% | Pass Yds | Pass TD | INT | Sacks | Y/A | Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2011 | BAL | 2 | 1 | 1 | 100.0 | 18 | 0 | 0 | 2 | 18.0 | 118.8 |
| 2012 | BAL | 5 | 29 | 17 | 58.6 | 179 | 0 | 1 | 3 | 6.2 | 62.3 |
| 2013 | BAL | 3 | 5 | 1 | 20.0 | 2 | 0 | 1 | 0 | 0.4 | 0.0 |
| 2015 | BUF | 14 | 380 | 242 | 63.7 | 3035 | 20 | 6 | 36 | 8.0 | 99.4 |
| 2016 | BUF | 15 | 436 | 269 | 61.7 | 3023 | 17 | 6 | 42 | 6.9 | 89.7 |
| 2017 | BUF | 16 | 457 | 280 | 61.3 | 2933 | 14 | 5 | 48 | 6.4 | 85.5 |
| 2018 | CLE | 4 | 85 | 42 | 49.4 | 473 | 2 | 2 | 13 | 5.6 | 64.5 |
| 2019 | LAC | 4 | 6 | 4 | 66.7 | 33 | 1 | 0 | 0 | 5.5 | 120.1 |
| 2020 | LAC | 2 | 30 | 16 | 53.3 | 208 | 0 | 0 | 2 | 6.9 | 75.4 |
| 2021 | HOU | 6 | 150 | 91 | 60.7 | 966 | 5 | 5 | 13 | 6.4 | 76.7 |
| 2022 | NYG | 2 | 8 | 6 | 75.0 | 58 | 1 | 1 | 3 | 7.2 | 94.8 |
| 2023 | NYG | 10 | 180 | 116 | 64.4 | 1341 | 5 | 3 | 17 | 7.4 | 89.1 |
| 2024 | NYJ | 2 | 22 | 17 | 77.3 | 119 | 3 | 0 | 0 | 5.4 | 128.6 |
| 2025 | NYJ | 6 | 134 | 80 | 59.7 | 779 | 5 | 5 | 14 | 5.8 | 72.9 |