Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
1986 players
Passing
| Jim Kelly | 480 | 285 | 3,593 | 22 | 17 | 7.5 |
| Frank Reich | 19 | 9 | 104 | 0 | 2 | 5.5 |
Rushing
| Robb Riddick | 150 | 632 | 4 | 4.2 |
| Greg Bell | 90 | 377 | 4 | 4.2 |
| Jim Kelly | 41 | 199 | 0 | 4.9 |
| Ronnie Harmon | 54 | 172 | 0 | 3.2 |
| Carl Byrum | 38 | 156 | 0 | 4.1 |
| Ricky Moore | 33 | 104 | 1 | 3.2 |
| Gary Wilkins | 3 | 18 | 0 | 6.0 |
| John Kidd | 1 | 0 | 0 | 0.0 |
| Frank Reich | 1 | 0 | 0 | 0.0 |
| Walter Broughton | 1 | -6 | 0 | -6.0 |
| Andre Reed | 3 | -8 | 0 | -2.7 |
Receiving
| Chris Burkett | 60 | 34 | 778 | 4 | 13.0 |
| Andre Reed | 96 | 53 | 739 | 7 | 7.7 |
| Pete Metzelaars | 71 | 49 | 485 | 3 | 6.8 |
| Robb Riddick | 65 | 49 | 468 | 1 | 7.2 |
| Jerry Butler | 28 | 15 | 302 | 2 | 10.8 |
| Ronnie Harmon | 35 | 22 | 185 | 1 | 5.3 |
| Ricky Moore | 30 | 23 | 184 | 0 | 6.1 |
| Greg Bell | 26 | 12 | 142 | 2 | 5.5 |
| Carl Byrum | 19 | 13 | 104 | 1 | 5.5 |
| Gary Wilkins | 11 | 8 | 74 | 0 | 6.7 |
| Walter Broughton | 5 | 3 | 71 | 0 | 14.2 |
| Jimmy Teal | 13 | 6 | 60 | 1 | 4.6 |
| Butch Rolle | 9 | 4 | 56 | 0 | 6.2 |
| Eric Richardson | 10 | 3 | 49 | 0 | 4.9 |
Defense
| Darryl Talley | LOLB/ROLB | 116 | 116 | 3.0 | 0 | 0 |
| Martin Bayless | SS | 102 | 102 | 1.0 | 1 | 0 |
| Bruce Smith | RDE | 63 | 63 | 15.0 | 0 | 2 |
| Dwight Drane | DB | 0 | 0 | 1.0 | 0 | 0 |
| Fred Smerlas | NT | 0 | 0 | 2.0 | 1 | 1 |
| Eugene Marve | LILB | 0 | 0 | 2.5 | 0 | 1 |
| George Cumby | RILB | 0 | 0 | 1.0 | 0 | 0 |
| Guy Frazier | LOLB | 0 | 0 | 1.0 | 0 | 0 |
| Mike Hamby | DE | 0 | 0 | 1.0 | 0 | 0 |
| Sean McNanie | LDE | 0 | 0 | 6.5 | 0 | 2 |
| Dean Prater | DE | 0 | 0 | 1.0 | 0 | 0 |
| Lucius Sanford | ROLB | 0 | 0 | 1.0 | 0 | 0 |