Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
2026 players
Passing
| Josh Allen | 138 | 91 | 1,249 | 7 | 4 | 9.1 |
Rushing
| James Cook | 95 | 532 | 5 | 5.6 |
| Josh Allen | 43 | 239 | 8 | 5.6 |
| Ray Davis | 4 | 8 | 0 | 2.0 |
| DJ Moore | 2 | 5 | 0 | 2.5 |
| Ty Johnson | 1 | 3 | 0 | 3.0 |
| Frank Gore Jr. | 1 | 3 | 0 | 3.0 |
| Dawson Knox | 1 | 0 | 0 | 0.0 |
Receiving
| Dalton Kincaid | 21 | 16 | 277 | 1 | 13.2 |
| Khalil Shakir | 26 | 18 | 256 | 0 | 9.8 |
| Keon Coleman | 18 | 15 | 224 | 2 | 12.4 |
| DJ Moore | 20 | 12 | 178 | 1 | 8.9 |
| Ty Johnson | 10 | 10 | 131 | 0 | 13.1 |
| Josh Palmer | 9 | 3 | 80 | 2 | 8.9 |
| Dawson Knox | 9 | 7 | 36 | 1 | 4.0 |
| Ray Davis | 2 | 2 | 35 | 0 | 17.5 |
| James Cook | 11 | 7 | 31 | 0 | 2.8 |
| Josh Allen | 1 | 1 | 1 | 0 | 1.0 |
Defense
| Dorian Williams | LB | 39 | 16 | 0.0 | 0 | 1 | 0 |
| Cole Bishop | SAF | 36 | 21 | 0.0 | 0 | 0 | 0 |
| Terrel Bernard | LB | 35 | 19 | 0.0 | 0 | 1 | 0 |
| Christian Benford | CB | 26 | 17 | 0.0 | 0 | 3 | 0 |
| Davison Igbinosun | CB | 25 | 15 | 0.0 | 0 | 4 | 0 |
| C.J. Gardner-Johnson | SAF | 25 | 16 | 0.0 | 1 | 2 | 0 |
| Greg Rousseau | LB | 20 | 14 | 6.0 | 0 | 3 | 3 |
| Bradley Chubb | OLB | 17 | 5 | 1.5 | 0 | 0 | 0 |
| Deone Walker | DT | 16 | 8 | 1.0 | 0 | 4 | 0 |
| Dee Alford | CB | 13 | 2 | 0.0 | 1 | 2 | 0 |
| DeWayne Carter | DT | 12 | 7 | 1.0 | 0 | 0 | 0 |
| Damar Hamlin | SAF | 12 | 6 | 0.0 | 0 | 0 | 0 |
| TJ Parker | LB | 11 | 5 | 0.5 | 0 | 0 | 1 |
| Michael Hoecht | LB | 10 | 2 | 0.5 | 0 | 1 | 0 |
| Maxwell Hairston | CB | 10 | 7 | 0.0 | 0 | 2 | 0 |
| Kaleb Elarms-Orr | LB | 10 | 3 | 0.0 | 0 | 1 | 0 |
| Ed Oliver | DT | 9 | 3 | 0.5 | 0 | 0 | 0 |
| Landon Jackson | DE | 9 | 3 | 0.0 | 0 | 1 | 0 |
| Greg Gaines | DT | 8 | 2 | 0.0 | 0 | 0 | 0 |
| Joe Andreessen | LB | 7 | 3 | 0.0 | 0 | 0 | 0 |
| Jordan Hancock | CB | 6 | 3 | 0.0 | 0 | 0 | 0 |
| Javon Solomon | LB | 5 | 3 | 0.0 | 0 | 0 | 0 |
| T.J. Sanders | DT | 5 | 2 | 0.0 | 0 | 0 | 0 |
| Keleki Latu | TE | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Sam Franklin Jr. | SAF | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Anthony Kendall | CB | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Dawson Knox | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Trent Sherfield | WR | 2 | 1 | 0.0 | 0 | 0 | 0 |
| DJ Moore | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Greg Dortch | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Palmer | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Te'Cory Couch | DB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Kani Walker | DB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Jalon Kilgore | SAF | 1 | 1 | 0.0 | 0 | 0 | 0 |