Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
1987 players
Passing
| Jim Kelly | 419 | 250 | 2,798 | 19 | 11 | 6.7 |
| Brian McClure | 38 | 20 | 181 | 0 | 3 | 4.8 |
| Willie Totten | 33 | 13 | 155 | 2 | 2 | 4.7 |
| Dan Manucci | 21 | 7 | 68 | 0 | 2 | 3.2 |
| Robb Riddick | 1 | 1 | 35 | 0 | 0 | 35.0 |
| Mark Miller | 3 | 1 | 9 | 0 | 1 | 3.0 |
| John Kidd | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Ronnie Harmon | 116 | 485 | 2 | 4.2 |
| Jamie Mueller | 82 | 354 | 2 | 4.3 |
| Carl Byrum | 66 | 280 | 0 | 4.2 |
| Robb Riddick | 59 | 221 | 5 | 3.7 |
| Ricky Porter | 47 | 177 | 0 | 3.8 |
| Jim Kelly | 29 | 133 | 0 | 4.6 |
| Johnny Shepherd | 12 | 42 | 0 | 3.5 |
| Bruce King | 9 | 28 | 0 | 3.1 |
| Leonard Williams | 9 | 25 | 0 | 2.8 |
| Rick Partridge | 1 | 13 | 0 | 13.0 |
| Willie Totten | 12 | 11 | 0 | 0.9 |
| Dan Manucci | 4 | 6 | 0 | 1.5 |
| Brian McClure | 2 | 4 | 0 | 2.0 |
| Andre Reed | 1 | 1 | 0 | 1.0 |
| Kerry Porter | 2 | 0 | 0 | 0.0 |
Receiving
| Chris Burkett | 79 | 56 | 765 | 4 | 9.7 |
| Andre Reed | 90 | 57 | 752 | 5 | 8.4 |
| Ronnie Harmon | 95 | 56 | 477 | 2 | 5.0 |
| Pete Metzelaars | 37 | 28 | 290 | 0 | 7.8 |
| Trumaine Johnson | 28 | 15 | 186 | 2 | 6.6 |
| Marc Brown | 19 | 9 | 120 | 1 | 6.3 |
| Sheldon Gaines | 18 | 9 | 115 | 0 | 6.4 |
| Robb Riddick | 19 | 15 | 96 | 3 | 5.1 |
| Walter Broughton | 8 | 5 | 90 | 1 | 11.2 |
| Keith McKeller | 12 | 9 | 80 | 0 | 6.7 |
| Ricky Porter | 15 | 9 | 70 | 0 | 4.7 |
| Thad McFadden | 15 | 4 | 41 | 1 | 2.7 |
| Jim Kelly | 1 | 1 | 35 | 0 | 35.0 |
| Reggie Bynum | 6 | 2 | 24 | 0 | 4.0 |
| Carl Byrum | 7 | 3 | 23 | 0 | 3.3 |
| Jamie Mueller | 5 | 3 | 13 | 0 | 2.6 |
| Joe Chetti | 1 | 1 | 9 | 0 | 9.0 |
| Veno Belk | 2 | 1 | 7 | 0 | 3.5 |
| Butch Rolle | 3 | 2 | 6 | 2 | 2.0 |
| Leonard Williams | 1 | 1 | 5 | 0 | 5.0 |
| Bruce King | 1 | 1 | 3 | 0 | 3.0 |
| Johnny Shepherd | 2 | 1 | 2 | 0 | 1.0 |
Defense
| Shane Conlan | LILB/LOLB | 114 | 114 | 0.5 | 0 | 0 |
| Scott Radecic | RILB | 81 | 81 | 0.0 | 2 | 1 |
| Darryl Talley | ROLB | 79 | 79 | 1.0 | 0 | 0 |
| Bruce Smith | RDE | 78 | 78 | 12.0 | 0 | 3 |
| Cornelius Bennett | LOLB | 69 | 69 | 8.5 | 0 | 4 |
| Nate Odomes | RCB | 42 | 42 | 0.0 | 0 | 0 |
| Roland Mitchell | DB | 2 | 2 | 0.0 | 0 | 0 |
| Ray Bentley | LB | 0 | 0 | 1.0 | 0 | 1 |
| Dwight Drane | SS | 0 | 0 | 1.0 | 0 | 0 |
| Leon Seals | DE | 0 | 0 | 3.5 | 0 | 2 |
| Fred Smerlas | NT | 0 | 0 | 1.0 | 0 | 0 |
| John Armstrong | DB | 0 | 0 | 2.0 | 0 | 1 |
| David Martin | DB | 0 | 0 | 1.0 | 0 | 0 |
| Sean McNanie | LDE | 0 | 0 | 2.5 | 0 | 0 |