Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
1988 players
Passing
| Jim Kelly | 452 | 269 | 3,380 | 15 | 17 | 7.5 |
| Robb Riddick | 2 | 2 | 31 | 0 | 0 | 15.5 |
Rushing
| Thurman Thomas | 207 | 881 | 2 | 4.3 |
| Robb Riddick | 111 | 438 | 12 | 3.9 |
| Jamie Mueller | 81 | 296 | 0 | 3.7 |
| Ronnie Harmon | 57 | 212 | 1 | 3.7 |
| Jim Kelly | 35 | 154 | 0 | 4.4 |
| Carl Byrum | 28 | 91 | 0 | 3.2 |
| Andre Reed | 6 | 64 | 0 | 10.7 |
| Frank Reich | 3 | -3 | 0 | -1.0 |
Receiving
| Andre Reed | 113 | 71 | 968 | 6 | 8.6 |
| Trumaine Johnson | 61 | 37 | 514 | 0 | 8.4 |
| Pete Metzelaars | 45 | 33 | 438 | 1 | 9.7 |
| Ronnie Harmon | 63 | 37 | 427 | 3 | 6.8 |
| Chris Burkett | 56 | 23 | 354 | 1 | 6.3 |
| Robb Riddick | 38 | 30 | 282 | 1 | 7.4 |
| Thurman Thomas | 27 | 18 | 208 | 0 | 7.7 |
| Flip Johnson | 11 | 9 | 170 | 1 | 15.5 |
| Jamie Mueller | 9 | 8 | 42 | 0 | 4.7 |
| Jim Kelly | 1 | 1 | 5 | 0 | 5.0 |
| Butch Rolle | 3 | 2 | 3 | 2 | 1.0 |
| Carl Byrum | 3 | 2 | 0 | 0 | 0.0 |
Defense
| Cornelius Bennett | LOLB | 103 | 103 | 9.5 | 2 | 3 |
| Shane Conlan | LILB | 84 | 84 | 1.5 | 1 | 1 |
| Darryl Talley | ROLB | 73 | 73 | 2.5 | 0 | 2 |
| Scott Radecic | LB | 57 | 57 | 1.5 | 0 | 0 |
| Bruce Smith | RDE | 56 | 56 | 11.0 | 0 | 2 |
| Nate Odomes | RCB | 44 | 44 | 0.0 | 1 | 1 |
| Jeff Wright | NT | 22 | 22 | 5.0 | 0 | 0 |
| Mark Pike | DE | 7 | 7 | 0.0 | 0 | 1 |
| Carlton Bailey | LB | 6 | 6 | 0.0 | 0 | 0 |
| Ray Bentley | RILB | 0 | 0 | 1.0 | 1 | 1 |
| Hal Garner | LB | 0 | 0 | 1.0 | 0 | 1 |
| Leon Seals | RDE | 0 | 0 | 2.0 | 0 | 0 |
| Fred Smerlas | NT | 0 | 0 | 4.0 | 0 | 0 |
| Art Still | LDE | 0 | 0 | 6.0 | 0 | 3 |