Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
1989 players
Passing
| Jim Kelly | 391 | 228 | 3,130 | 25 | 18 | 8.0 |
| Frank Reich | 87 | 53 | 701 | 7 | 2 | 8.1 |
Rushing
| Thurman Thomas | 298 | 1,244 | 6 | 4.2 |
| Larry Kinnebrew | 131 | 533 | 6 | 4.1 |
| Kenneth Davis | 29 | 149 | 1 | 5.1 |
| Jim Kelly | 29 | 137 | 2 | 4.7 |
| Ronnie Harmon | 17 | 99 | 0 | 5.8 |
| Jamie Mueller | 16 | 44 | 0 | 2.8 |
| Andre Reed | 2 | 31 | 0 | 15.5 |
| Frank Reich | 9 | 30 | 0 | 3.3 |
| Stan Gelbaugh | 1 | -3 | 0 | -3.0 |
Receiving
| Andre Reed | 155 | 88 | 1,312 | 9 | 8.5 |
| Thurman Thomas | 81 | 60 | 669 | 6 | 8.3 |
| Ronnie Harmon | 48 | 29 | 363 | 4 | 7.6 |
| Keith McKeller | 26 | 20 | 341 | 2 | 13.1 |
| Don Beebe | 26 | 17 | 317 | 2 | 12.2 |
| Flip Johnson | 56 | 25 | 303 | 1 | 5.4 |
| Pete Metzelaars | 24 | 18 | 179 | 2 | 7.5 |
| James Lofton | 19 | 8 | 166 | 3 | 8.7 |
| Kenneth Davis | 8 | 6 | 92 | 2 | 11.5 |
| Larry Kinnebrew | 9 | 5 | 60 | 0 | 6.7 |
| Jamie Mueller | 1 | 1 | 8 | 0 | 8.0 |
| Butch Rolle | 2 | 1 | 1 | 1 | 0.5 |
Defense
| Darryl Talley | ROLB | 97 | 97 | 6.0 | 0 | 0 |
| Bruce Smith | RDE | 88 | 88 | 13.0 | 0 | 0 |
| Scott Radecic | LILB | 77 | 77 | 1.5 | 0 | 1 |
| Cornelius Bennett | LOLB | 54 | 54 | 5.5 | 2 | 0 |
| Shane Conlan | LILB | 50 | 50 | 1.0 | 1 | 1 |
| Nate Odomes | RCB | 46 | 46 | 1.0 | 5 | 2 |
| Carlton Bailey | LB | 27 | 27 | 0.0 | 1 | 0 |
| Jeff Wright | NT | 15 | 15 | 3.0 | 1 | 1 |
| Mark Pike | DE | 3 | 3 | 0.0 | 0 | 2 |
| Leon Seals | DE | 0 | 0 | 4.0 | 0 | 1 |
| Fred Smerlas | NT | 0 | 0 | 1.0 | 0 | 3 |
| Derrick Burroughs | DB | 0 | 0 | 1.0 | 0 | 0 |