Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
1990 players
Passing
| Jim Kelly | 346 | 219 | 2,829 | 24 | 9 | 8.2 |
| Frank Reich | 63 | 36 | 469 | 2 | 0 | 7.4 |
| Gale Gilbert | 15 | 8 | 106 | 2 | 2 | 7.1 |
| Don Smith | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Thurman Thomas | 271 | 1,297 | 11 | 4.8 |
| Kenneth Davis | 64 | 302 | 4 | 4.7 |
| Jamie Mueller | 59 | 207 | 2 | 3.5 |
| Don Smith | 20 | 82 | 2 | 4.1 |
| Jim Kelly | 22 | 63 | 0 | 2.9 |
| Carwell Gardner | 15 | 41 | 0 | 2.7 |
| Frank Reich | 15 | 24 | 0 | 1.6 |
| Don Beebe | 1 | 23 | 0 | 23.0 |
| Andre Reed | 3 | 23 | 0 | 7.7 |
| Larry Kinnebrew | 9 | 18 | 1 | 2.0 |
Receiving
| Andre Reed | 105 | 71 | 945 | 8 | 9.0 |
| James Lofton | 61 | 35 | 712 | 4 | 11.7 |
| Thurman Thomas | 74 | 49 | 532 | 2 | 7.2 |
| Keith McKeller | 60 | 34 | 464 | 5 | 7.7 |
| Don Smith | 29 | 21 | 225 | 0 | 7.8 |
| Don Beebe | 24 | 11 | 221 | 1 | 9.2 |
| Jamie Mueller | 20 | 16 | 106 | 1 | 5.3 |
| Kenneth Davis | 10 | 9 | 78 | 1 | 7.8 |
| Pete Metzelaars | 14 | 10 | 60 | 1 | 4.3 |
| Steve Tasker | 2 | 2 | 44 | 2 | 22.0 |
| Al Edwards | 5 | 2 | 11 | 0 | 2.2 |
| Butch Rolle | 3 | 3 | 6 | 3 | 2.0 |
Defense
| Darryl Talley | ROLB | 123 | 123 | 4.0 | 2 | 0 |
| Bruce Smith | RDE | 101 | 101 | 19.0 | 0 | 5 |
| Cornelius Bennett | LOLB | 96 | 96 | 4.0 | 0 | 3 |
| Shane Conlan | LILB | 93 | 93 | 1.0 | 0 | 0 |
| Jeff Wright | NT | 76 | 76 | 5.0 | 0 | 0 |
| Carlton Bailey | RILB | 57 | 57 | 2.0 | 0 | 2 |
| Nate Odomes | RCB | 42 | 42 | 0.0 | 1 | 2 |
| James Williams | LCB | 38 | 38 | 0.0 | 2 | 0 |
| Marvcus Patton | LB | 12 | 12 | 0.5 | 0 | 0 |
| David Pool | DB | 10 | 10 | 0.0 | 1 | 0 |
| Mark Pike | DE | 9 | 9 | 0.0 | 0 | 0 |
| Mike Lodish | DE | 6 | 6 | 2.0 | 0 | 0 |
| Hal Garner | LB | 0 | 0 | 0.5 | 0 | 0 |
| Leon Seals | LDE | 0 | 0 | 4.0 | 1 | 1 |