Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
1991 players
Passing
| Jim Kelly | 474 | 304 | 3,844 | 33 | 17 | 8.1 |
| Frank Reich | 41 | 27 | 305 | 6 | 2 | 7.4 |
| Chris Mohr | 1 | 1 | -9 | 0 | 0 | -9.0 |
Rushing
| Thurman Thomas | 288 | 1,407 | 7 | 4.9 |
| Kenneth Davis | 129 | 624 | 4 | 4.8 |
| Carwell Gardner | 42 | 146 | 4 | 3.5 |
| Andre Reed | 12 | 136 | 0 | 11.3 |
| Jim Kelly | 20 | 45 | 1 | 2.2 |
| Al Edwards | 1 | 17 | 0 | 17.0 |
| Frank Reich | 13 | 6 | 0 | 0.5 |
Receiving
| Andre Reed | 126 | 81 | 1,113 | 10 | 8.8 |
| James Lofton | 101 | 57 | 1,072 | 8 | 10.6 |
| Thurman Thomas | 73 | 62 | 631 | 5 | 8.6 |
| Keith McKeller | 70 | 44 | 434 | 3 | 6.2 |
| Don Beebe | 55 | 32 | 414 | 6 | 7.5 |
| Al Edwards | 36 | 22 | 228 | 1 | 6.3 |
| Kenneth Davis | 23 | 20 | 118 | 1 | 5.1 |
| Pete Metzelaars | 6 | 5 | 54 | 2 | 9.0 |
| Steve Tasker | 2 | 2 | 39 | 1 | 19.5 |
| Carwell Gardner | 6 | 3 | 20 | 0 | 3.3 |
| Butch Rolle | 4 | 3 | 10 | 2 | 2.5 |
| Mike Alexander | 4 | 1 | 7 | 0 | 1.8 |
Defense
| Shane Conlan | LILB | 122 | 122 | 0.0 | 0 | 1 |
| Darryl Talley | ROLB | 117 | 117 | 4.0 | 5 | 5 |
| Cornelius Bennett | LOLB | 107 | 107 | 9.0 | 0 | 3 |
| Carlton Bailey | RILB | 93 | 93 | 0.0 | 0 | 0 |
| Nate Odomes | RCB | 76 | 76 | 1.0 | 5 | 2 |
| Phil Hansen | RDE | 40 | 40 | 2.0 | 0 | 1 |
| Mike Lodish | NT | 37 | 37 | 1.5 | 0 | 2 |
| Jeff Wright | NT | 33 | 33 | 6.0 | 0 | 0 |
| Bruce Smith | RDE | 18 | 18 | 1.5 | 0 | 0 |
| Cliff Hicks | DB | 17 | 17 | 0.0 | 1 | 0 |
| James Williams | DB | 16 | 16 | 0.0 | 1 | 0 |
| Marvcus Patton | LB | 10 | 10 | 0.0 | 0 | 0 |
| Henry Jones | DB | 8 | 8 | 0.0 | 0 | 0 |
| Mark Pike | DE | 6 | 6 | 0.0 | 0 | 1 |
| Kirby Jackson | LCB | 0 | 0 | 1.0 | 4 | 1 |
| Reggie Rogers | DE | 0 | 0 | 1.0 | 0 | 0 |
| Leon Seals | LDE | 0 | 0 | 1.0 | 0 | 1 |
| Leonard Smith | SS | 0 | 0 | 2.0 | 3 | 0 |