Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
1992 players
Passing
| Jim Kelly | 462 | 269 | 3,457 | 23 | 19 | 7.5 |
| Frank Reich | 47 | 24 | 221 | 0 | 2 | 4.7 |
Rushing
| Thurman Thomas | 312 | 1,487 | 9 | 4.8 |
| Kenneth Davis | 139 | 613 | 6 | 4.4 |
| Carwell Gardner | 40 | 166 | 2 | 4.2 |
| Andre Reed | 8 | 65 | 0 | 8.1 |
| Jim Kelly | 31 | 53 | 1 | 1.7 |
| Eddie Fuller | 6 | 39 | 0 | 6.5 |
| Chris Mohr | 1 | 11 | 0 | 11.0 |
| Steve Tasker | 1 | 9 | 0 | 9.0 |
| Al Edwards | 1 | 8 | 0 | 8.0 |
| Don Beebe | 1 | -6 | 0 | -6.0 |
| Frank Reich | 9 | -9 | 0 | -1.0 |
Receiving
| Andre Reed | 107 | 65 | 913 | 3 | 8.5 |
| James Lofton | 110 | 51 | 786 | 6 | 7.1 |
| Thurman Thomas | 87 | 58 | 626 | 3 | 7.2 |
| Don Beebe | 60 | 33 | 554 | 2 | 9.2 |
| Pete Metzelaars | 43 | 30 | 298 | 6 | 6.9 |
| Brad Lamb | 13 | 7 | 139 | 0 | 10.7 |
| Keith McKeller | 16 | 14 | 110 | 0 | 6.9 |
| Kenneth Davis | 18 | 15 | 80 | 0 | 4.4 |
| Carwell Gardner | 9 | 7 | 67 | 0 | 7.4 |
| Robert Awalt | 8 | 4 | 34 | 0 | 4.2 |
| Al Edwards | 2 | 2 | 25 | 0 | 12.5 |
| Steve Tasker | 6 | 2 | 24 | 0 | 4.0 |
| Eddie Fuller | 5 | 2 | 17 | 0 | 3.4 |
| Mitch Frerotte | 2 | 2 | 4 | 2 | 2.0 |
| John Fina | 1 | 1 | 1 | 1 | 1.0 |
Defense
| Darryl Talley | ROLB | 106 | 106 | 4.0 | 0 | 2 |
| Henry Jones | SS | 92 | 92 | 0.0 | 8 | 1 |
| Bruce Smith | RDE | 89 | 89 | 14.0 | 0 | 3 |
| Shane Conlan | LILB | 82 | 82 | 2.0 | 1 | 0 |
| Cornelius Bennett | LOLB | 81 | 81 | 4.0 | 0 | 2 |
| Jeff Wright | NT | 70 | 70 | 6.0 | 0 | 1 |
| Carlton Bailey | RILB | 65 | 65 | 1.0 | 0 | 2 |
| Phil Hansen | LDE | 64 | 64 | 8.0 | 0 | 1 |
| Nate Odomes | RCB | 63 | 63 | 1.0 | 5 | 0 |
| Mark Maddox | LB | 25 | 25 | 0.0 | 0 | 1 |
| Marvcus Patton | LB | 25 | 25 | 2.0 | 0 | 0 |
| Matt Darby | DB | 23 | 23 | 0.0 | 0 | 0 |
| James Williams | LCB | 15 | 15 | 0.0 | 2 | 0 |
| Kurt Schulz | DB | 14 | 14 | 0.0 | 0 | 0 |
| Mike Lodish | NT | 7 | 7 | 0.0 | 0 | 0 |
| Richard Harvey | LB | 6 | 6 | 0.0 | 0 | 0 |
| Cliff Hicks | DB | 6 | 6 | 1.0 | 0 | 0 |
| Mark Pike | DE | 5 | 5 | 1.0 | 0 | 0 |
| Keith Goganious | LB | 4 | 4 | 0.0 | 0 | 1 |