Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
1993 players
Passing
| Jim Kelly | 470 | 288 | 3,382 | 18 | 18 | 7.2 |
| Frank Reich | 26 | 16 | 153 | 2 | 0 | 5.9 |
| Thurman Thomas | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Thurman Thomas | 355 | 1,315 | 6 | 3.7 |
| Kenneth Davis | 109 | 391 | 6 | 3.6 |
| Jim Kelly | 36 | 102 | 0 | 2.8 |
| Carwell Gardner | 20 | 56 | 0 | 2.8 |
| Nate Turner | 11 | 36 | 0 | 3.3 |
| Bill Brooks | 3 | 30 | 0 | 10.0 |
| Andre Reed | 9 | 21 | 0 | 2.3 |
| John Fina | 1 | -2 | 0 | -2.0 |
| Frank Reich | 6 | -6 | 0 | -1.0 |
Receiving
| Andre Reed | 88 | 52 | 854 | 6 | 9.7 |
| Bill Brooks | 85 | 60 | 714 | 5 | 8.4 |
| Pete Metzelaars | 95 | 68 | 609 | 4 | 6.4 |
| Don Beebe | 66 | 31 | 504 | 3 | 7.6 |
| Thurman Thomas | 72 | 48 | 387 | 0 | 5.4 |
| Russell Copeland | 17 | 13 | 242 | 0 | 14.2 |
| Kenneth Davis | 24 | 21 | 95 | 0 | 4.0 |
| Carwell Gardner | 7 | 4 | 50 | 1 | 7.1 |
| Keith McKeller | 4 | 3 | 35 | 1 | 8.8 |
| Steve Tasker | 5 | 2 | 26 | 0 | 5.2 |
| Robert Awalt | 4 | 2 | 19 | 0 | 4.8 |
Defense
| Darryl Talley | ROLB | 136 | 136 | 2.0 | 3 | 4 |
| Marvcus Patton | LILB | 118 | 118 | 1.0 | 2 | 3 |
| Bruce Smith | RDE | 108 | 108 | 14.0 | 1 | 4 |
| Cornelius Bennett | LOLB | 102 | 102 | 5.0 | 1 | 2 |
| Henry Jones | SS | 83 | 83 | 2.0 | 2 | 3 |
| Jeff Wright | NT | 79 | 79 | 4.5 | 0 | 3 |
| Mark Maddox | RILB | 62 | 62 | 0.0 | 0 | 2 |
| Keith Goganious | RILB | 55 | 55 | 1.0 | 0 | 0 |
| Matt Darby | DB | 53 | 53 | 0.0 | 2 | 1 |
| Nate Odomes | RCB | 47 | 47 | 0.0 | 9 | 1 |
| Phil Hansen | LDE | 43 | 43 | 3.5 | 0 | 2 |
| Mickey Washington | LCB | 41 | 41 | 0.5 | 1 | 0 |
| James Williams | LCB | 40 | 40 | 0.0 | 2 | 0 |
| Oliver Barnett | LDE | 36 | 36 | 2.0 | 0 | 0 |
| Kurt Schulz | DB | 10 | 10 | 0.0 | 0 | 0 |
| Thomas Smith | DB | 7 | 7 | 0.0 | 0 | 0 |
| Mike Lodish | NT | 7 | 7 | 0.5 | 0 | 0 |
| Mark Pike | DE | 5 | 5 | 0.0 | 0 | 0 |
| Richard Harvey | LB | 4 | 4 | 0.0 | 0 | 2 |
| Monty Brown | LB | 3 | 3 | 0.0 | 0 | 0 |
| John Parrella | DT | 2 | 2 | 1.0 | 0 | 0 |