Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
1995 players
Passing
| Jim Kelly | 458 | 255 | 3,130 | 22 | 13 | 6.8 |
| Todd Collins | 29 | 14 | 112 | 0 | 1 | 3.9 |
| Alex Van Pelt | 18 | 10 | 106 | 2 | 0 | 5.9 |
| Justin Armour | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Thurman Thomas | 267 | 1,005 | 6 | 3.8 |
| Darick Holmes | 172 | 698 | 4 | 4.1 |
| Carwell Gardner | 20 | 77 | 0 | 3.8 |
| Steve Tasker | 8 | 74 | 0 | 9.2 |
| Andre Reed | 7 | 48 | 0 | 6.9 |
| Yonel Jourdain | 8 | 31 | 0 | 3.9 |
| Todd Collins | 9 | 23 | 0 | 2.6 |
| Jim Kelly | 17 | 20 | 0 | 1.2 |
| Tim Tindale | 5 | 16 | 0 | 3.2 |
| Bill Brooks | 3 | 7 | 0 | 2.3 |
| Russell Copeland | 1 | -1 | 0 | -1.0 |
| Justin Armour | 4 | -5 | 0 | -1.2 |
Receiving
| Bill Brooks | 88 | 53 | 763 | 11 | 8.7 |
| Russell Copeland | 95 | 42 | 646 | 1 | 6.8 |
| Lonnie Johnson | 81 | 49 | 504 | 1 | 6.2 |
| Andre Reed | 43 | 24 | 312 | 3 | 7.3 |
| Justin Armour | 41 | 26 | 300 | 3 | 7.3 |
| Steve Tasker | 36 | 20 | 255 | 3 | 7.1 |
| Thurman Thomas | 41 | 26 | 220 | 2 | 5.4 |
| Darick Holmes | 34 | 24 | 214 | 0 | 6.3 |
| Tony Cline | 13 | 8 | 64 | 0 | 4.9 |
| Rob Coons | 5 | 3 | 28 | 0 | 5.6 |
| Damon Thomas | 2 | 1 | 18 | 0 | 9.0 |
| Carwell Gardner | 8 | 2 | 17 | 0 | 2.1 |
| Yonel Jourdain | 1 | 1 | 7 | 0 | 7.0 |
Defense
| Cornelius Bennett | RILB | 104 | 81 | 2.0 | 1 | 1 |
| Bryce Paup | LOLB | 89 | 70 | 17.5 | 2 | 3 |
| Henry Jones | SS | 78 | 57 | 0.0 | 1 | 0 |
| Phil Hansen | LDE | 76 | 53 | 10.0 | 0 | 0 |
| Bruce Smith | RDE | 74 | 52 | 10.5 | 0 | 1 |
| Monty Brown | LILB | 69 | 45 | 0.0 | 0 | 0 |
| Marlo Perry | LILB | 59 | 44 | 0.0 | 0 | 0 |
| Kurt Schulz | FS | 55 | 39 | 0.0 | 6 | 2 |
| Ted Washington | NT | 53 | 42 | 2.5 | 0 | 0 |
| Sam Rogers | ROLB | 45 | 32 | 2.0 | 0 | 1 |
| Thomas Smith | RCB | 41 | 37 | 0.0 | 2 | 0 |
| Marlon Kerner | LCB | 34 | 29 | 0.0 | 0 | 1 |
| Jeff Burris | LCB | 34 | 28 | 0.0 | 1 | 0 |
| Greg Evans | DB | 25 | 18 | 0.0 | 1 | 0 |
| Ken Irvin | DB | 20 | 18 | 0.0 | 0 | 0 |
| Mark Maddox | LB | 18 | 13 | 0.0 | 0 | 1 |
| Matt Darby | DB | 16 | 14 | 0.0 | 2 | 1 |
| Damien Covington | LB | 15 | 9 | 0.0 | 0 | 0 |
| Jim Jeffcoat | DE | 14 | 9 | 2.5 | 0 | 2 |
| Chris Green | DB | 12 | 9 | 0.0 | 0 | 0 |
| Karl Wilson | DE | 9 | 6 | 1.0 | 0 | 0 |
| Ed Philion | DT | 9 | 8 | 0.0 | 0 | 0 |
| David White | LB | 7 | 6 | 1.0 | 1 | 2 |
| Mark Pike | DE | 6 | 3 | 0.0 | 0 | 0 |
| John Holecek | LB | 5 | 3 | 0.0 | 0 | 0 |
| Filmel Johnson | DB | 5 | 5 | 0.0 | 0 | 0 |