Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
1996 players
Passing
| Jim Kelly | 379 | 222 | 2,810 | 14 | 19 | 7.4 |
| Todd Collins | 99 | 55 | 739 | 4 | 5 | 7.5 |
| Alex Van Pelt | 5 | 2 | 9 | 0 | 0 | 1.8 |
Rushing
| Thurman Thomas | 281 | 1,033 | 8 | 3.7 |
| Darick Holmes | 189 | 571 | 4 | 3.0 |
| Jim Kelly | 19 | 66 | 2 | 3.5 |
| Tim Tindale | 14 | 49 | 0 | 3.5 |
| Eric Moulds | 12 | 44 | 0 | 3.7 |
| Todd Collins | 21 | 43 | 0 | 2.0 |
| Quinn Early | 3 | 39 | 0 | 13.0 |
| Steve Tasker | 9 | 31 | 0 | 3.4 |
| Andre Reed | 8 | 22 | 0 | 2.8 |
| Jason Bratton | 4 | 8 | 0 | 2.0 |
| Alex Van Pelt | 3 | -5 | 0 | -1.7 |
Receiving
| Andre Reed | 101 | 66 | 1,036 | 6 | 10.3 |
| Quinn Early | 91 | 50 | 798 | 4 | 8.8 |
| Lonnie Johnson | 80 | 46 | 457 | 0 | 5.7 |
| Steve Tasker | 33 | 21 | 372 | 3 | 11.3 |
| Eric Moulds | 37 | 20 | 279 | 2 | 7.5 |
| Thurman Thomas | 42 | 26 | 254 | 0 | 6.0 |
| Tony Cline | 29 | 19 | 117 | 1 | 4.0 |
| Darick Holmes | 21 | 16 | 102 | 1 | 4.9 |
| Russell Copeland | 19 | 7 | 85 | 0 | 4.5 |
| Chris Brantley | 8 | 5 | 47 | 1 | 5.9 |
| Rob Coons | 1 | 1 | 12 | 0 | 12.0 |
| Corey Louchiey | 2 | 1 | 0 | 0 | 0.0 |
| Tim Tindale | 3 | 1 | -1 | 0 | -0.3 |
Defense
| Chris Spielman | LILB | 157 | 111 | 0.0 | 1 | 1 |
| Ted Washington | NT | 92 | 70 | 3.5 | 0 | 0 |
| Bruce Smith | RDE | 90 | 69 | 13.5 | 0 | 5 |
| Phil Hansen | LDE | 80 | 60 | 8.0 | 0 | 1 |
| Mark Maddox | RILB | 71 | 46 | 0.0 | 0 | 2 |
| Kurt Schulz | FS | 68 | 53 | 0.0 | 4 | 0 |
| Sam Rogers | ROLB | 58 | 38 | 3.5 | 0 | 0 |
| Jeff Burris | LCB | 50 | 41 | 0.0 | 1 | 1 |
| Bryce Paup | LOLB | 48 | 38 | 6.0 | 0 | 2 |
| Thomas Smith | RCB | 43 | 38 | 0.0 | 1 | 0 |
| Matt Stevens | SS | 33 | 26 | 0.0 | 2 | 0 |
| Emanuel Martin | DB | 29 | 20 | 0.0 | 2 | 0 |
| Henry Jones | SS | 25 | 19 | 0.0 | 0 | 0 |
| David White | LOLB | 22 | 16 | 0.5 | 0 | 1 |
| Damien Covington | LB | 21 | 15 | 0.0 | 0 | 0 |
| Ken Irvin | DB | 21 | 17 | 2.0 | 0 | 0 |
| Marlo Perry | LB | 21 | 15 | 0.0 | 1 | 0 |
| Gabe Northern | LB/DE | 19 | 16 | 5.0 | 0 | 0 |
| Marlon Kerner | DB | 17 | 16 | 1.0 | 1 | 0 |
| Jim Jeffcoat | DE | 10 | 8 | 5.0 | 0 | 0 |
| Shawn Price | DE | 8 | 5 | 0.0 | 0 | 0 |
| Sean Moran | DE | 5 | 4 | 0.0 | 0 | 0 |
| Raymond Jackson | DB | 4 | 4 | 0.0 | 1 | 0 |