Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
2008 players
Passing
| Trent Edwards | 374 | 245 | 2,699 | 11 | 10 | 7.2 |
| J.P. Losman | 104 | 63 | 584 | 2 | 5 | 5.6 |
| Brian Moorman | 1 | 1 | 19 | 1 | 0 | 19.0 |
Rushing
| Marshawn Lynch | 251 | 1,047 | 8 | 4.2 |
| Fred Jackson | 129 | 560 | 3 | 4.3 |
| Trent Edwards | 36 | 117 | 3 | 3.2 |
| J.P. Losman | 12 | 70 | 2 | 5.8 |
| Lee Evans | 1 | 22 | 0 | 22.0 |
| Roscoe Parrish | 2 | 9 | 0 | 4.5 |
| Keith Ellison | 1 | 6 | 0 | 6.0 |
| Steve Johnson | 1 | 6 | 0 | 6.0 |
| Xavier Omon | 6 | 5 | 0 | 0.8 |
Receiving
| Lee Evans | 63 | 1,017 | 3 | 16.1 |
| Josh Reed | 56 | 597 | 1 | 10.7 |
| Robert Royal | 33 | 351 | 1 | 10.6 |
| Fred Jackson | 37 | 317 | 0 | 8.6 |
| Marshawn Lynch | 47 | 300 | 1 | 6.4 |
| Roscoe Parrish | 24 | 232 | 1 | 9.7 |
| Derek Schouman | 15 | 153 | 1 | 10.2 |
| Steve Johnson | 10 | 102 | 2 | 10.2 |
| Derek Fine | 10 | 94 | 1 | 9.4 |
| James Hardy | 9 | 87 | 2 | 9.7 |
| Ryan Denney | 1 | 19 | 1 | 19.0 |
| Corey McIntyre | 2 | -1 | 0 | -0.5 |
Defense
| Paul Posluszny | MLB | 83 | 60 | 0.0 | 1 | 6 | 1 |
| Kawika Mitchell | OLB | 69 | 44 | 4.0 | 2 | 3 | 2 |
| Keith Ellison | ILB | 62 | 38 | 0.0 | 0 | 2 | 0 |
| Bryan Scott | LB | 59 | 46 | 1.0 | 0 | 3 | 1 |
| Terrence McGee | CB | 59 | 54 | 0.0 | 3 | 18 | 0 |
| Ko Simpson | S | 55 | 40 | 0.0 | 0 | 2 | 0 |
| Donte Whitner | S | 51 | 40 | 1.0 | 0 | 1 | 1 |
| Kyle Williams | DT | 43 | 24 | 3.5 | 0 | 0 | 1 |
| Chris Kelsay | DE | 40 | 26 | 2.0 | 0 | 5 | 1 |
| Ryan Denney | DE | 38 | 20 | 4.0 | 0 | 7 | 1 |
| Marcus Stroud | DE | 34 | 17 | 1.0 | 0 | 8 | 1 |
| Jabari Greer | CB | 33 | 27 | 0.0 | 2 | 7 | 0 |
| Leodis McKelvin | CB | 30 | 24 | 0.0 | 2 | 5 | 1 |
| Spencer Johnson | DT | 23 | 12 | 2.0 | 0 | 3 | 0 |
| George Wilson | S | 20 | 15 | 1.5 | 0 | 0 | 0 |
| Reggie Corner | DB | 19 | 16 | 0.0 | 0 | 4 | 1 |
| Ashton Youboty | CB | 17 | 16 | 1.0 | 0 | 2 | 0 |
| Aaron Schobel | DE | 15 | 14 | 1.0 | 0 | 1 | 0 |
| Copeland Bryan | DE | 14 | 9 | 1.0 | 0 | 2 | 0 |
| Blake Costanzo | OLB | 14 | 14 | 0.0 | 0 | 0 | 2 |
| John Wendling | FS | 13 | 10 | 0.0 | 0 | 0 | 0 |
| Jon Corto | DB | 8 | 8 | 0.0 | 0 | 0 | 1 |
| Dustin Fox | DB | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Lee Evans | WR | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Rian Lindell | K | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Teddy Lehman | LB | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Chris Ellis | OLB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Steve Johnson | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Justin Jenkins | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| John DiGiorgio | MLB | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Corey McIntyre | FB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Melvin Fowler | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Robert Royal | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Reed | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Langston Walker | OT | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Fred Jackson | RB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Roscoe Parrish | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jason Peters | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Brad Butler | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Corey Mace | DT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Derek Schouman | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| James Hardy | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Derek Fine | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |