Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
2016 players
Passing
| Tyrod Taylor | 436 | 269 | 3,023 | 17 | 6 | 6.9 |
| EJ Manuel | 26 | 11 | 131 | 0 | 0 | 5.0 |
| Cardale Jones | 11 | 6 | 96 | 0 | 1 | 8.7 |
| Jonathan Williams | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| LeSean McCoy | 234 | 1,267 | 13 | 5.4 |
| Tyrod Taylor | 95 | 580 | 6 | 6.1 |
| Mike Gillislee | 101 | 577 | 8 | 5.7 |
| Jonathan Williams | 27 | 94 | 1 | 3.5 |
| Brandon Tate | 3 | 48 | 0 | 16.0 |
| EJ Manuel | 8 | 22 | 0 | 2.8 |
| Colton Schmidt | 1 | 16 | 0 | 16.0 |
| Jerome Felton | 8 | 13 | 0 | 1.6 |
| Percy Harvin | 1 | 11 | 0 | 11.0 |
| Robert Woods | 1 | 6 | 0 | 6.0 |
| Cardale Jones | 1 | -1 | 0 | -1.0 |
| Reggie Bush | 12 | -3 | 1 | -0.2 |
Receiving
| Robert Woods | 76 | 51 | 613 | 1 | 8.1 |
| Charles Clay | 87 | 57 | 552 | 4 | 6.3 |
| Marquise Goodwin | 68 | 29 | 431 | 3 | 6.3 |
| Sammy Watkins | 52 | 28 | 430 | 2 | 8.3 |
| LeSean McCoy | 57 | 50 | 356 | 1 | 6.2 |
| Justin Hunter | 24 | 10 | 189 | 4 | 7.9 |
| Walt Powell | 25 | 14 | 142 | 0 | 5.7 |
| Brandon Tate | 11 | 8 | 117 | 0 | 10.6 |
| Nick O'Leary | 14 | 9 | 114 | 0 | 8.1 |
| Reggie Bush | 10 | 7 | 90 | 0 | 9.0 |
| Greg Salas | 6 | 4 | 89 | 1 | 14.8 |
| Jerome Felton | 9 | 6 | 57 | 0 | 6.3 |
| Mike Gillislee | 11 | 9 | 50 | 1 | 4.5 |
| Gerald Christian | 2 | 1 | 14 | 0 | 7.0 |
| Percy Harvin | 4 | 2 | 6 | 0 | 1.5 |
| Jonathan Williams | 2 | 1 | 0 | 0 | 0.0 |