Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
2018 players
Passing
| Josh Allen | 319 | 168 | 2,044 | 10 | 12 | 6.4 |
| Derek Anderson | 70 | 42 | 465 | 0 | 4 | 6.6 |
| Nathan Peterman | 81 | 44 | 296 | 1 | 7 | 3.7 |
| Matt Barkley | 25 | 15 | 232 | 2 | 0 | 9.3 |
| Logan Thomas | 1 | 1 | 15 | 0 | 0 | 15.0 |
| Zay Jones | 1 | 0 | 0 | 0 | 0 | 0.0 |
| Corey Bojorquez | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Josh Allen | 89 | 631 | 8 | 7.1 |
| LeSean McCoy | 161 | 514 | 3 | 3.2 |
| Chris Ivory | 115 | 385 | 1 | 3.3 |
| Marcus Murphy | 52 | 250 | 0 | 4.8 |
| Keith Ford | 21 | 79 | 0 | 3.8 |
| Isaiah McKenzie | 10 | 66 | 2 | 6.6 |
| Nathan Peterman | 10 | 50 | 1 | 5.0 |
| Patrick DiMarco | 1 | 9 | 0 | 9.0 |
| Ray-Ray McCloud | 2 | 4 | 0 | 2.0 |
| Zay Jones | 1 | 0 | 0 | 0.0 |
| Corey Bojorquez | 1 | 0 | 0 | 0.0 |
| Derek Anderson | 1 | -1 | 0 | -1.0 |
| Terrelle Pryor | 1 | -1 | 0 | -1.0 |
| Matt Barkley | 3 | -2 | 0 | -0.7 |
Receiving
| Zay Jones | 102 | 56 | 652 | 7 | 6.4 |
| Robert Foster | 44 | 27 | 541 | 3 | 12.3 |
| Jason Croom | 35 | 22 | 259 | 1 | 7.4 |
| Terrelle Pryor | 30 | 16 | 252 | 2 | 8.4 |
| LeSean McCoy | 46 | 34 | 238 | 0 | 5.2 |
| Charles Clay | 36 | 21 | 184 | 0 | 5.1 |
| Isaiah McKenzie | 30 | 18 | 179 | 0 | 6.0 |
| Chris Ivory | 20 | 12 | 175 | 0 | 8.8 |
| Deonte Thompson | 30 | 17 | 161 | 0 | 5.4 |
| Logan Thomas | 17 | 12 | 77 | 0 | 4.5 |
| Patrick DiMarco | 4 | 3 | 62 | 0 | 15.5 |
| Ray-Ray McCloud | 6 | 5 | 36 | 0 | 6.0 |
| Marcus Murphy | 19 | 11 | 26 | 0 | 1.4 |
| Keith Ford | 5 | 3 | 21 | 0 | 4.2 |
| Victor Bolden | 4 | 1 | 10 | 0 | 2.5 |
| Kyle Williams | 1 | 1 | 9 | 0 | 9.0 |
| Cam Phillips | 1 | 1 | 9 | 0 | 9.0 |
| Jeremy Kerley | 4 | 2 | 7 | 0 | 1.8 |
| Dion Dawkins | 1 | 1 | 7 | 1 | 7.0 |
| Khari Lee | 1 | 1 | 5 | 0 | 5.0 |
Defense
| Tremaine Edmunds | MLB | 111 | 70 | 2.0 | 2 | 12 | 2 |
| Jordan Poyer | FS | 85 | 58 | 2.0 | 4 | 6 | 1 |
| Matt Milano | OLB | 69 | 43 | 1.0 | 3 | 7 | 0 |
| Lorenzo Alexander | OLB | 67 | 48 | 6.5 | 2 | 9 | 2 |
| Micah Hyde | S | 53 | 36 | 0.0 | 2 | 5 | 0 |
| Tre'Davious White | CB | 51 | 41 | 0.0 | 2 | 8 | 0 |
| Rafael Bush | DB | 43 | 28 | 1.5 | 0 | 0 | 0 |
| Taron Johnson | CB | 37 | 29 | 1.0 | 1 | 3 | 1 |
| Levi Wallace | DB | 33 | 20 | 0.0 | 0 | 3 | 0 |
| Harrison Phillips | DT | 31 | 16 | 0.0 | 0 | 0 | 0 |
| Kyle Williams | DT | 31 | 18 | 5.0 | 0 | 1 | 1 |
| Jerry Hughes | DE | 29 | 22 | 7.0 | 0 | 1 | 3 |
| Shaq Lawson | DE | 28 | 16 | 4.0 | 0 | 5 | 2 |
| Eddie Yarbrough | DE | 26 | 18 | 0.0 | 0 | 0 | 0 |
| Jordan Phillips | DT | 22 | 13 | 1.0 | 0 | 4 | 0 |
| Trent Murphy | DE | 20 | 10 | 4.0 | 0 | 1 | 2 |
| Star Lotulelei | DT | 15 | 8 | 0.0 | 0 | 1 | 0 |
| Ryan Lewis | CB | 15 | 12 | 0.0 | 0 | 3 | 2 |
| Corey Thompson | LB | 14 | 8 | 0.0 | 0 | 0 | 1 |
| Siran Neal | CB | 11 | 10 | 1.0 | 0 | 0 | 1 |
| Julian Stanford | LB | 11 | 9 | 1.0 | 0 | 1 | 1 |
| Lafayette Pitts | CB | 9 | 8 | 0.0 | 0 | 0 | 0 |
| Deon Lacey | LB | 8 | 6 | 0.0 | 0 | 0 | 0 |
| Denzel Rice | DB | 5 | 4 | 0.0 | 1 | 1 | 0 |
| Taiwan Jones | RB | 5 | 5 | 0.0 | 0 | 0 | 0 |
| Mike Love | DE | 5 | 0 | 0.0 | 0 | 0 | 0 |
| Dean Marlowe | S | 5 | 4 | 0.0 | 0 | 1 | 0 |
| Nate Orchard | DE | 4 | 3 | 0.0 | 0 | 1 | 0 |
| Jason Croom | TE | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Marcus Murphy | RB | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Robert Foster | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Patrick DiMarco | RB | 3 | 3 | 0.0 | 0 | 0 | 1 |
| Reid Ferguson | LS | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Dion Dawkins | OT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Ryan Groy | G | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Logan Thomas | TE | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Zay Jones | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Deonte Thompson | WR | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Jordan Mills | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Chris Ivory | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Vontae Davis | CB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jeremiah Sirles | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Victor Bolden | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Russell Bodine | C | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Matt Darr | P | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Isaiah McKenzie | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Wyatt Teller | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Cam Phillips | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Allen | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |