Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
2019 players
Passing
| Josh Allen | 461 | 271 | 3,089 | 20 | 9 | 6.7 |
| Matt Barkley | 51 | 27 | 359 | 0 | 3 | 7.0 |
| John Brown | 1 | 1 | 28 | 1 | 0 | 28.0 |
Rushing
| Devin Singletary | 151 | 775 | 2 | 5.1 |
| Frank Gore | 166 | 599 | 2 | 3.6 |
| Josh Allen | 109 | 510 | 9 | 4.7 |
| T.J. Yeldon | 17 | 63 | 0 | 3.7 |
| Isaiah McKenzie | 8 | 49 | 0 | 6.1 |
| Robert Foster | 2 | 29 | 0 | 14.5 |
| Dawson Knox | 1 | 9 | 0 | 9.0 |
| Andre Roberts | 1 | 7 | 0 | 7.0 |
| John Brown | 2 | 7 | 0 | 3.5 |
| Patrick DiMarco | 3 | 7 | 0 | 2.3 |
| Senorise Perry | 3 | 3 | 0 | 1.0 |
| Matt Barkley | 2 | -4 | 0 | -2.0 |
Receiving
| John Brown | 115 | 72 | 1,060 | 6 | 9.2 |
| Cole Beasley | 106 | 67 | 778 | 6 | 7.3 |
| Dawson Knox | 50 | 28 | 388 | 2 | 7.8 |
| Isaiah McKenzie | 39 | 27 | 254 | 1 | 6.5 |
| Devin Singletary | 41 | 29 | 194 | 2 | 4.7 |
| Duke Williams | 19 | 12 | 166 | 1 | 8.7 |
| T.J. Yeldon | 15 | 13 | 124 | 0 | 8.3 |
| Tommy Sweeney | 13 | 8 | 114 | 0 | 8.8 |
| Frank Gore | 16 | 13 | 100 | 0 | 6.2 |
| Tyler Kroft | 14 | 6 | 71 | 1 | 5.1 |
| Robert Foster | 18 | 3 | 64 | 0 | 3.6 |
| Patrick DiMarco | 7 | 5 | 41 | 0 | 5.9 |
| Lee Smith | 5 | 4 | 31 | 1 | 6.2 |
| Andre Roberts | 7 | 3 | 20 | 0 | 2.9 |
| Senorise Perry | 1 | 1 | 1 | 0 | 1.0 |
| Dion Dawkins | 1 | 1 | 1 | 1 | 1.0 |
Defense
| Tremaine Edmunds | MLB | 96 | 47 | 1.5 | 1 | 9 | 0 |
| Matt Milano | OLB | 92 | 56 | 1.5 | 0 | 9 | 1 |
| Jordan Poyer | FS | 91 | 55 | 1.0 | 2 | 3 | 3 |
| Levi Wallace | DB | 67 | 57 | 0.0 | 2 | 9 | 0 |
| Micah Hyde | S | 64 | 42 | 0.0 | 1 | 2 | 2 |
| Tre'Davious White | CB | 54 | 44 | 1.0 | 6 | 17 | 2 |
| Lorenzo Alexander | OLB | 48 | 28 | 2.0 | 0 | 9 | 1 |
| Taron Johnson | CB | 46 | 35 | 1.0 | 0 | 5 | 1 |
| Ed Oliver | DT | 38 | 19 | 5.0 | 0 | 2 | 1 |
| Trent Murphy | DE | 33 | 21 | 5.0 | 1 | 3 | 2 |
| Siran Neal | CB | 33 | 25 | 0.0 | 0 | 0 | 1 |
| Kevin Johnson | CB | 33 | 22 | 1.0 | 0 | 5 | 0 |
| Shaq Lawson | DE | 30 | 19 | 6.5 | 0 | 2 | 1 |
| Jordan Phillips | DT | 25 | 19 | 9.5 | 0 | 0 | 1 |
| Jerry Hughes | DE | 20 | 11 | 4.5 | 0 | 3 | 0 |
| Star Lotulelei | DT | 17 | 10 | 2.0 | 1 | 1 | 0 |
| Darryl Johnson | OLB | 13 | 8 | 1.0 | 0 | 0 | 0 |
| Corey Liuget | DT | 11 | 8 | 1.0 | 0 | 0 | 0 |
| Dean Marlowe | S | 11 | 10 | 0.0 | 0 | 1 | 0 |
| Maurice Alexander | LB | 9 | 6 | 0.0 | 0 | 0 | 0 |
| Jaquan Johnson | DB | 7 | 6 | 0.0 | 0 | 0 | 0 |
| Julian Stanford | LB | 7 | 5 | 0.0 | 0 | 0 | 0 |
| Corey Thompson | LB | 5 | 2 | 0.0 | 0 | 0 | 0 |
| Senorise Perry | RB | 5 | 4 | 0.0 | 0 | 0 | 0 |
| Robert Foster | WR | 5 | 5 | 0.0 | 0 | 0 | 0 |
| Harrison Phillips | DT | 3 | 1 | 0.5 | 0 | 2 | 0 |
| Quinton Spain | G | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Lee Smith | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Kurt Coleman | S | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Spencer Long | C | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Vincent Taylor | DT | 2 | 2 | 0.0 | 0 | 1 | 0 |
| Jon Feliciano | G | 2 | 2 | 0.0 | 0 | 0 | 0 |
| T.J. Yeldon | RB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Reid Ferguson | LS | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Patrick DiMarco | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dion Dawkins | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Allen | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |