Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
2021 players
Passing
| Josh Allen | 646 | 409 | 4,407 | 36 | 15 | 6.8 |
| Mitchell Trubisky | 8 | 6 | 43 | 0 | 1 | 5.4 |
| Cole Beasley | 1 | 0 | 0 | 0 | 0 | 0.0 |
Rushing
| Devin Singletary | 188 | 870 | 7 | 4.6 |
| Josh Allen | 122 | 763 | 6 | 6.3 |
| Zack Moss | 96 | 345 | 4 | 3.6 |
| Matt Breida | 26 | 125 | 1 | 4.8 |
| Isaiah McKenzie | 9 | 47 | 1 | 5.2 |
| Emmanuel Sanders | 2 | 31 | 0 | 15.5 |
| Mitchell Trubisky | 13 | 24 | 1 | 1.8 |
| Reggie Gilliam | 3 | 3 | 0 | 1.0 |
| Davis Webb | 2 | -3 | 0 | -1.5 |
Receiving
| Stefon Diggs | 164 | 103 | 1,225 | 10 | 7.5 |
| Cole Beasley | 112 | 82 | 693 | 1 | 6.2 |
| Emmanuel Sanders | 72 | 42 | 626 | 4 | 8.7 |
| Dawson Knox | 71 | 49 | 587 | 9 | 8.3 |
| Gabe Davis | 63 | 35 | 549 | 6 | 8.7 |
| Devin Singletary | 50 | 40 | 228 | 1 | 4.6 |
| Zack Moss | 32 | 23 | 197 | 1 | 6.2 |
| Isaiah McKenzie | 26 | 20 | 178 | 1 | 6.8 |
| Matt Breida | 9 | 7 | 72 | 2 | 8.0 |
| Tommy Sweeney | 12 | 9 | 44 | 1 | 3.7 |
| Jake Kumerow | 6 | 2 | 28 | 0 | 4.7 |
| Reggie Gilliam | 5 | 3 | 23 | 0 | 4.6 |
Defense
| Tremaine Edmunds | MLB | 90 | 52 | 0.0 | 1 | 4 | 0 |
| Jordan Poyer | FS | 85 | 58 | 3.0 | 5 | 9 | 0 |
| Matt Milano | OLB | 74 | 45 | 3.0 | 0 | 5 | 0 |
| Micah Hyde | S | 70 | 49 | 1.0 | 5 | 10 | 1 |
| Taron Johnson | CB | 65 | 42 | 3.0 | 1 | 7 | 1 |
| Levi Wallace | DB | 53 | 42 | 0.0 | 2 | 10 | 0 |
| Harrison Phillips | DT | 46 | 23 | 1.0 | 0 | 1 | 0 |
| Greg Rousseau | DE | 43 | 35 | 4.0 | 1 | 4 | 1 |
| Dane Jackson | CB | 39 | 31 | 0.0 | 0 | 6 | 0 |
| Tre'Davious White | CB | 37 | 23 | 0.5 | 1 | 6 | 1 |
| Ed Oliver | DT | 36 | 24 | 4.0 | 0 | 3 | 1 |
| A.J. Klein | OLB | 28 | 22 | 0.0 | 1 | 5 | 0 |
| Mario Addison | DL | 26 | 17 | 7.0 | 0 | 0 | 2 |
| Siran Neal | CB | 21 | 14 | 0.0 | 0 | 0 | 1 |
| Jerry Hughes | DE | 17 | 7 | 2.0 | 0 | 3 | 2 |
| Tyler Matakevich | ILB | 17 | 10 | 0.0 | 1 | 1 | 0 |
| Star Lotulelei | DT | 16 | 10 | 3.0 | 0 | 0 | 0 |
| Carlos Basham | LB | 14 | 7 | 2.5 | 0 | 0 | 0 |
| A.J. Epenesa | DE | 14 | 8 | 1.5 | 0 | 1 | 0 |
| Tyrel Dodson | LB | 12 | 7 | 0.0 | 0 | 0 | 0 |
| Jaquan Johnson | DB | 11 | 5 | 0.0 | 1 | 1 | 0 |
| Efe Obada | DE | 11 | 7 | 3.5 | 0 | 1 | 0 |
| Eli Ankou | DT | 10 | 3 | 1.0 | 0 | 0 | 0 |
| Andre Smith | LB | 9 | 3 | 0.0 | 0 | 0 | 0 |
| Vernon Butler | DT | 8 | 3 | 0.0 | 0 | 0 | 0 |
| Cam Lewis | CB | 7 | 3 | 0.0 | 0 | 1 | 1 |
| Justin Zimmer | DT | 7 | 1 | 1.0 | 0 | 0 | 0 |
| Taiwan Jones | RB | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Jake Kumerow | WR | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Stefon Diggs | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Reggie Gilliam | FB | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Allen | QB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Brandin Bryant | DT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Joe Giles-Harris | LB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Dawson Knox | TE | 2 | 2 | 0.0 | 0 | 0 | 1 |
| Matt Breida | RB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Emmanuel Sanders | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Isaiah McKenzie | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dion Dawkins | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Cody Ford | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ike Boettger | G | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Tyler Bass | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Devin Singletary | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Zack Moss | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Gabe Davis | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Damar Hamlin | SAF | 1 | 1 | 0.0 | 0 | 2 | 0 |
| Spencer Brown | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |