Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
2022 players
Passing
| Josh Allen | 567 | 359 | 4,283 | 35 | 14 | 7.6 |
| Case Keenum | 7 | 2 | 8 | 0 | 0 | 1.1 |
Rushing
| Devin Singletary | 177 | 819 | 5 | 4.6 |
| Josh Allen | 124 | 762 | 7 | 6.1 |
| James Cook | 89 | 507 | 2 | 5.7 |
| Isaiah McKenzie | 9 | 55 | 1 | 6.1 |
| Nyheim Hines | 24 | 33 | 1 | 1.4 |
| Duke Johnson | 2 | 4 | 0 | 2.0 |
| Case Keenum | 5 | 0 | 0 | 0.0 |
| Stefon Diggs | 1 | -3 | 0 | -3.0 |
Receiving
| Stefon Diggs | 154 | 108 | 1,429 | 11 | 9.3 |
| Gabe Davis | 93 | 48 | 836 | 7 | 9.0 |
| Dawson Knox | 65 | 48 | 517 | 6 | 8.0 |
| Isaiah McKenzie | 65 | 42 | 423 | 4 | 6.5 |
| Devin Singletary | 52 | 38 | 280 | 1 | 5.4 |
| Nyheim Hines | 37 | 30 | 241 | 1 | 6.5 |
| James Cook | 32 | 21 | 180 | 1 | 5.6 |
| Khalil Shakir | 20 | 10 | 161 | 1 | 8.0 |
| Quintin Morris | 11 | 8 | 84 | 1 | 7.6 |
| Reggie Gilliam | 10 | 8 | 69 | 1 | 6.9 |
| Jake Kumerow | 7 | 4 | 64 | 0 | 9.1 |
| Jamison Crowder | 13 | 6 | 60 | 0 | 4.6 |
| John Brown | 2 | 1 | 42 | 1 | 21.0 |
| Cole Beasley | 7 | 6 | 35 | 0 | 5.0 |
| Tommy Sweeney | 1 | 1 | 7 | 0 | 7.0 |
Defense
| Tremaine Edmunds | MLB | 94 | 58 | 1.0 | 1 | 7 | 0 |
| Matt Milano | OLB | 85 | 58 | 1.5 | 3 | 11 | 0 |
| Damar Hamlin | SAF | 82 | 54 | 1.5 | 0 | 2 | 1 |
| Taron Johnson | CB | 76 | 53 | 0.0 | 1 | 9 | 0 |
| Jordan Poyer | FS | 55 | 36 | 0.0 | 4 | 8 | 1 |
| Dane Jackson | CB | 48 | 40 | 0.0 | 2 | 12 | 1 |
| Kaiir Elam | CB | 41 | 29 | 0.0 | 2 | 4 | 0 |
| Greg Rousseau | DE | 33 | 23 | 8.0 | 0 | 4 | 1 |
| DaQuan Jones | DT | 31 | 15 | 2.0 | 0 | 0 | 0 |
| Jaquan Johnson | DB | 30 | 14 | 0.0 | 1 | 1 | 0 |
| Ed Oliver | DT | 29 | 15 | 2.5 | 0 | 3 | 1 |
| Tyrel Dodson | LB | 28 | 18 | 1.0 | 0 | 0 | 0 |
| Shaq Lawson | DE | 28 | 16 | 3.5 | 0 | 1 | 1 |
| Christian Benford | CB | 23 | 16 | 0.0 | 1 | 5 | 0 |
| Cam Lewis | CB | 21 | 15 | 0.0 | 0 | 0 | 0 |
| Von Miller | OLB | 20 | 17 | 8.0 | 0 | 2 | 1 |
| Tre'Davious White | CB | 19 | 15 | 0.0 | 1 | 6 | 0 |
| Terrel Bernard | LB | 18 | 7 | 0.0 | 0 | 0 | 0 |
| Siran Neal | CB | 18 | 12 | 0.0 | 0 | 4 | 0 |
| Carlos Basham | LB | 18 | 8 | 2.0 | 1 | 2 | 0 |
| Jordan Phillips | DT | 17 | 6 | 1.5 | 0 | 2 | 0 |
| A.J. Klein | OLB | 15 | 10 | 0.0 | 0 | 0 | 0 |
| A.J. Epenesa | DE | 15 | 12 | 6.5 | 0 | 5 | 2 |
| Tim Settle | DT | 14 | 6 | 1.0 | 0 | 1 | 1 |
| Dean Marlowe | S | 12 | 8 | 0.0 | 0 | 0 | 0 |
| Baylon Spector | LB | 5 | 5 | 0.0 | 0 | 0 | 0 |
| Taiwan Jones | RB | 5 | 2 | 0.0 | 0 | 0 | 0 |
| Kingsley Jonathan | DE | 4 | 1 | 0.0 | 0 | 0 | 0 |
| Micah Hyde | S | 4 | 1 | 0.0 | 0 | 0 | 0 |
| Tyler Matakevich | ILB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Quintin Morris | TE | 3 | 2 | 0.0 | 0 | 0 | 1 |
| Prince Emili | DT | 3 | 0 | 0.0 | 0 | 1 | 0 |
| Dawson Knox | TE | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Devin Singletary | RB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Brandin Bryant | DT | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Xavier Rhodes | CB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Tyler Bass | K | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Reggie Gilliam | FB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| C.J. Brewer | DT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Josh Allen | QB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Ja'Marcus Ingram | CB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Jake Kumerow | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Nyheim Hines | RB | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Gabe Davis | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Dion Dawkins | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Isaiah McKenzie | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Jamison Crowder | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Mitch Morse | C | 1 | 0 | 0.0 | 0 | 0 | 0 |
| David Quessenberry | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Joe Giles-Harris | LB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| James Cook | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Khalil Shakir | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |