Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
2023 players
Passing
| Josh Allen | 579 | 385 | 4,306 | 29 | 18 | 7.4 |
Rushing
| James Cook | 237 | 1,122 | 2 | 4.7 |
| Josh Allen | 111 | 524 | 15 | 4.7 |
| Latavius Murray | 79 | 300 | 4 | 3.8 |
| Ty Johnson | 30 | 132 | 0 | 4.4 |
| Damien Harris | 23 | 94 | 1 | 4.1 |
| Leonard Fournette | 12 | 40 | 0 | 3.3 |
| Khalil Shakir | 1 | 10 | 0 | 10.0 |
| Stefon Diggs | 1 | 5 | 0 | 5.0 |
| Deonte Harty | 4 | 0 | 0 | 0.0 |
| Gabe Davis | 1 | -2 | 0 | -2.0 |
| Kyle Allen | 13 | -13 | 0 | -1.0 |
Receiving
| Stefon Diggs | 160 | 107 | 1,183 | 8 | 7.4 |
| Gabe Davis | 81 | 45 | 746 | 7 | 9.2 |
| Dalton Kincaid | 91 | 73 | 673 | 2 | 7.4 |
| Khalil Shakir | 45 | 39 | 611 | 2 | 13.6 |
| James Cook | 54 | 44 | 445 | 4 | 8.2 |
| Dawson Knox | 36 | 22 | 186 | 2 | 5.2 |
| Deonte Harty | 21 | 15 | 150 | 1 | 7.1 |
| Latavius Murray | 22 | 17 | 119 | 0 | 5.4 |
| Trent Sherfield | 22 | 11 | 86 | 1 | 3.9 |
| Ty Johnson | 7 | 7 | 62 | 1 | 8.9 |
| Quintin Morris | 3 | 2 | 26 | 1 | 8.7 |
| Damien Harris | 2 | 2 | 16 | 0 | 8.0 |
| Reggie Gilliam | 1 | 1 | 3 | 0 | 3.0 |
Defense
| Terrel Bernard | LB | 127 | 68 | 6.5 | 3 | 5 | 0 |
| Jordan Poyer | FS | 92 | 58 | 1.0 | 0 | 4 | 1 |
| Taron Johnson | CB | 85 | 59 | 1.0 | 0 | 8 | 3 |
| Tyrel Dodson | LB | 61 | 44 | 2.5 | 0 | 2 | 1 |
| Rasul Douglas | CB | 58 | 44 | 1.0 | 5 | 14 | 0 |
| Christian Benford | CB | 49 | 38 | 0.0 | 2 | 10 | 2 |
| Micah Hyde | S | 45 | 28 | 0.0 | 2 | 7 | 0 |
| Taylor Rapp | SAF | 44 | 27 | 0.5 | 1 | 2 | 0 |
| Ed Oliver | DT | 42 | 25 | 9.5 | 1 | 3 | 0 |
| Greg Rousseau | DE | 39 | 27 | 5.0 | 0 | 4 | 1 |
| Dorian Williams | LB | 38 | 23 | 0.0 | 0 | 1 | 0 |
| Dane Jackson | CB | 35 | 30 | 0.0 | 0 | 5 | 1 |
| Matt Milano | OLB | 27 | 15 | 0.0 | 2 | 2 | 1 |
| Leonard Floyd | DE | 26 | 15 | 10.5 | 0 | 1 | 1 |
| A.J. Epenesa | DE | 20 | 9 | 6.5 | 2 | 8 | 1 |
| Cam Lewis | CB | 19 | 15 | 0.0 | 0 | 2 | 0 |
| DaQuan Jones | DT | 14 | 6 | 2.5 | 0 | 0 | 0 |
| Jordan Phillips | DT | 13 | 8 | 2.5 | 0 | 5 | 0 |
| Kaiir Elam | CB | 13 | 9 | 0.0 | 0 | 0 | 0 |
| Siran Neal | CB | 13 | 9 | 0.0 | 0 | 0 | 0 |
| Tim Settle | DT | 12 | 7 | 1.0 | 0 | 0 | 0 |
| Shaq Lawson | DE | 12 | 6 | 1.0 | 0 | 0 | 0 |
| Linval Joseph | DT | 11 | 6 | 1.0 | 0 | 0 | 0 |
| Tre'Davious White | CB | 10 | 8 | 0.0 | 1 | 2 | 0 |
| Poona Ford | DT | 6 | 2 | 1.0 | 0 | 0 | 0 |
| Tyler Matakevich | ILB | 6 | 3 | 0.0 | 0 | 0 | 0 |
| Baylon Spector | LB | 6 | 2 | 0.0 | 0 | 0 | 0 |
| Gabe Davis | WR | 4 | 4 | 0.0 | 0 | 0 | 0 |
| Josh Norman | CB | 4 | 3 | 0.0 | 0 | 0 | 0 |
| Kingsley Jonathan | DE | 4 | 2 | 0.0 | 0 | 0 | 1 |
| Mitch Morse | C | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Stefon Diggs | WR | 3 | 3 | 0.0 | 0 | 0 | 0 |
| Reid Ferguson | LS | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Reggie Gilliam | FB | 3 | 2 | 0.0 | 0 | 0 | 1 |
| Trent Sherfield | WR | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Dalton Kincaid | TE | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Von Miller | OLB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Ty Johnson | RB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Damar Hamlin | SAF | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Connor McGovern | C | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Latavius Murray | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Deonte Harty | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Kendal Vickers | DE | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Tyler Bass | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| James Cook | RB | 1 | 1 | 0.0 | 0 | 0 | 0 |