Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
2024 players
Passing
| Josh Allen | 483 | 307 | 3,731 | 28 | 6 | 7.7 |
| Mitchell Trubisky | 26 | 19 | 179 | 2 | 0 | 6.9 |
| Mike White | 11 | 3 | 28 | 0 | 0 | 2.5 |
Rushing
| James Cook | 207 | 1,009 | 16 | 4.9 |
| Josh Allen | 102 | 531 | 12 | 5.2 |
| Ray Davis | 113 | 442 | 3 | 3.9 |
| Ty Johnson | 41 | 213 | 1 | 5.2 |
| Curtis Samuel | 5 | 14 | 0 | 2.8 |
| Keon Coleman | 1 | 9 | 0 | 9.0 |
| Reggie Gilliam | 3 | 7 | 0 | 2.3 |
| Khalil Shakir | 2 | 4 | 0 | 2.0 |
| Mitchell Trubisky | 17 | 1 | 0 | 0.1 |
Receiving
| Khalil Shakir | 100 | 76 | 821 | 4 | 8.2 |
| Keon Coleman | 57 | 29 | 556 | 4 | 9.8 |
| Amari Cooper | 85 | 44 | 547 | 4 | 6.4 |
| Dalton Kincaid | 75 | 44 | 448 | 2 | 6.0 |
| Mack Hollins | 50 | 31 | 378 | 5 | 7.6 |
| Dawson Knox | 33 | 22 | 311 | 1 | 9.4 |
| Ty Johnson | 25 | 18 | 284 | 3 | 11.4 |
| James Cook | 38 | 32 | 258 | 2 | 6.8 |
| Curtis Samuel | 46 | 31 | 253 | 1 | 5.5 |
| Ray Davis | 19 | 17 | 189 | 3 | 9.9 |
| Tyrell Shavers | 1 | 1 | 69 | 1 | 69.0 |
| Quintin Morris | 8 | 5 | 36 | 1 | 4.5 |
| Zach Davidson | 2 | 1 | 5 | 0 | 2.5 |
Defense
| Dorian Williams | LB | 103 | 55 | 0.0 | 0 | 0 | 1 |
| Terrel Bernard | LB | 94 | 45 | 1.0 | 2 | 3 | 0 |
| Damar Hamlin | SAF | 79 | 52 | 0.0 | 2 | 5 | 0 |
| Taylor Rapp | SAF | 75 | 41 | 0.0 | 2 | 6 | 1 |
| Taron Johnson | CB | 61 | 38 | 1.0 | 2 | 5 | 1 |
| Christian Benford | CB | 60 | 46 | 1.0 | 2 | 10 | 2 |
| Cam Lewis | CB | 60 | 40 | 0.0 | 1 | 4 | 0 |
| Rasul Douglas | CB | 54 | 39 | 0.0 | 0 | 5 | 1 |
| Greg Rousseau | DE | 48 | 31 | 8.0 | 0 | 3 | 3 |
| Cole Bishop | SAF | 38 | 23 | 0.0 | 0 | 2 | 1 |
| A.J. Epenesa | DE | 36 | 20 | 6.0 | 0 | 2 | 2 |
| Baylon Spector | LB | 35 | 17 | 1.5 | 0 | 0 | 0 |
| Ed Oliver | DT | 28 | 13 | 3.0 | 0 | 0 | 3 |
| Joe Andreessen | LB | 26 | 12 | 0.0 | 0 | 0 | 0 |
| Kaiir Elam | CB | 25 | 16 | 0.0 | 0 | 2 | 0 |
| Ja'Marcus Ingram | CB | 23 | 15 | 1.0 | 2 | 4 | 0 |
| DaQuan Jones | DT | 22 | 10 | 2.5 | 0 | 1 | 0 |
| Austin Johnson | NT | 18 | 6 | 0.5 | 2 | 2 | 0 |
| Casey Toohill | DE | 17 | 6 | 1.0 | 0 | 1 | 0 |
| Dawuane Smoot | DE | 15 | 11 | 1.5 | 0 | 1 | 2 |
| Von Miller | OLB | 15 | 11 | 6.0 | 0 | 0 | 0 |
| Matt Milano | OLB | 14 | 5 | 0.0 | 0 | 0 | 0 |
| Quinton Jefferson | DE | 12 | 3 | 2.0 | 0 | 0 | 0 |
| Javon Solomon | DE | 11 | 7 | 2.0 | 0 | 0 | 1 |
| DeWayne Carter | DT | 11 | 8 | 0.0 | 0 | 1 | 0 |
| Brandon Codrington | CB | 7 | 6 | 0.0 | 0 | 1 | 0 |
| Ty Johnson | RB | 6 | 6 | 0.0 | 0 | 0 | 0 |
| Edefuan Ulofoshio | LB | 5 | 4 | 0.0 | 0 | 1 | 0 |
| Jordan Phillips | DT | 5 | 3 | 0.0 | 1 | 1 | 0 |
| Reggie Gilliam | FB | 4 | 1 | 0.0 | 0 | 0 | 0 |
| Eli Ankou | DT | 4 | 0 | 0.0 | 0 | 0 | 0 |
| Kareem Jackson | S | 4 | 2 | 0.0 | 0 | 0 | 0 |
| Quintin Morris | TE | 4 | 1 | 0.0 | 0 | 0 | 0 |
| Nicholas Morrow | LB | 3 | 0 | 0.0 | 0 | 0 | 0 |
| Curtis Samuel | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Zion Logue | DT | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Mack Hollins | WR | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Jalen Virgil | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Reid Ferguson | LS | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Tyler Bass | K | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Allen | QB | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ryan Van Demark | OT | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Keon Coleman | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |