Franchise 57 seasons 437–443–2 all-time 21 playoff trips 0 Super Bowls
2025 players
Passing
| Josh Allen | 460 | 319 | 3,668 | 25 | 10 | 8.0 |
| Mitchell Trubisky | 35 | 25 | 313 | 4 | 0 | 8.9 |
Rushing
| James Cook | 309 | 1,621 | 12 | 5.2 |
| Josh Allen | 112 | 579 | 14 | 5.2 |
| Ray Davis | 58 | 275 | 0 | 4.7 |
| Ty Johnson | 50 | 200 | 3 | 4.0 |
| Elijah Moore | 6 | 24 | 1 | 4.0 |
| Mitchell Trubisky | 9 | 6 | 0 | 0.7 |
| Khalil Shakir | 1 | 5 | 0 | 5.0 |
| Reggie Gilliam | 2 | 4 | 0 | 2.0 |
Receiving
| Khalil Shakir | 95 | 72 | 719 | 4 | 7.6 |
| Dalton Kincaid | 49 | 39 | 571 | 5 | 11.7 |
| Dawson Knox | 49 | 36 | 417 | 4 | 8.5 |
| Keon Coleman | 59 | 38 | 404 | 4 | 6.8 |
| Josh Palmer | 37 | 22 | 303 | 0 | 8.2 |
| James Cook | 40 | 33 | 291 | 2 | 7.3 |
| Brandin Cooks | 36 | 24 | 279 | 0 | 7.8 |
| Ty Johnson | 33 | 24 | 263 | 2 | 8.0 |
| Tyrell Shavers | 23 | 15 | 245 | 1 | 10.7 |
| Jackson Hawes | 19 | 16 | 187 | 3 | 9.8 |
| Gabe Davis | 18 | 12 | 129 | 1 | 7.2 |
| Elijah Moore | 17 | 9 | 112 | 0 | 6.6 |
| Ray Davis | 13 | 10 | 86 | 2 | 6.6 |
| Curtis Samuel | 9 | 7 | 81 | 1 | 9.0 |
| Keleki Latu | 4 | 4 | 35 | 0 | 8.8 |
| Reggie Gilliam | 2 | 2 | 24 | 0 | 12.0 |
Defense
| Cole Bishop | SAF | 84 | 52 | 2.0 | 3 | 7 | 0 |
| Jordan Poyer | FS | 70 | 31 | 0.5 | 1 | 3 | 0 |
| Matt Milano | OLB | 65 | 34 | 3.5 | 0 | 0 | 1 |
| Dorian Williams | LB | 62 | 28 | 0.0 | 0 | 2 | 0 |
| Terrel Bernard | LB | 60 | 39 | 0.0 | 1 | 3 | 0 |
| Taron Johnson | CB | 57 | 34 | 0.0 | 0 | 4 | 0 |
| Shaq Thompson | OLB | 56 | 33 | 1.0 | 0 | 2 | 1 |
| Greg Rousseau | LB | 45 | 23 | 7.0 | 0 | 2 | 1 |
| Cam Lewis | CB | 43 | 33 | 0.0 | 0 | 4 | 2 |
| Christian Benford | CB | 42 | 31 | 2.0 | 2 | 4 | 0 |
| Tre'Davious White | CB | 39 | 28 | 0.0 | 1 | 10 | 0 |
| Deone Walker | DT | 37 | 15 | 1.0 | 0 | 4 | 0 |
| Joe Andreessen | LB | 33 | 12 | 0.0 | 0 | 0 | 0 |
| A.J. Epenesa | LB | 32 | 17 | 2.5 | 2 | 4 | 0 |
| Joey Bosa | DE | 29 | 17 | 5.0 | 0 | 2 | 5 |
| Taylor Rapp | SAF | 26 | 17 | 0.0 | 0 | 0 | 0 |
| Jordan Hancock | CB | 22 | 9 | 0.0 | 0 | 0 | 0 |
| DaQuan Jones | DT | 21 | 10 | 3.0 | 1 | 2 | 1 |
| Larry Ogunjobi | DT | 19 | 10 | 0.0 | 0 | 0 | 0 |
| Maxwell Hairston | CB | 18 | 14 | 0.0 | 2 | 5 | 0 |
| Darnell Savage | SAF | 18 | 10 | 0.0 | 0 | 3 | 1 |
| Javon Solomon | LB | 17 | 11 | 1.0 | 0 | 0 | 0 |
| T.J. Sanders | DT | 16 | 7 | 1.0 | 0 | 1 | 0 |
| Phidarian Mathis | DT | 13 | 4 | 0.0 | 0 | 0 | 0 |
| Reggie Gilliam | RB | 13 | 6 | 0.0 | 0 | 0 | 0 |
| Sam Franklin Jr. | SAF | 13 | 10 | 0.0 | 0 | 0 | 0 |
| Ed Oliver | DT | 11 | 9 | 3.0 | 0 | 0 | 1 |
| Dorian Strong | CB | 10 | 9 | 0.0 | 0 | 0 | 0 |
| Jordan Phillips | DT | 9 | 5 | 1.0 | 0 | 1 | 0 |
| Keonta Jenkins | LB | 9 | 5 | 0.0 | 0 | 0 | 0 |
| Andre Jones Jr. | LB | 5 | 1 | 0.0 | 0 | 0 | 0 |
| Michael Hoecht | LB | 5 | 2 | 2.0 | 0 | 0 | 1 |
| Baylon Spector | LB | 3 | 2 | 0.0 | 0 | 0 | 0 |
| Dane Jackson | CB | 3 | 0 | 0.0 | 0 | 0 | 0 |
| Keleki Latu | TE | 3 | 1 | 0.0 | 0 | 0 | 0 |
| Ty Johnson | RB | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Tyrell Shavers | WR | 2 | 1 | 0.0 | 0 | 0 | 0 |
| Zion Logue | DT | 2 | 1 | 0.5 | 0 | 1 | 0 |
| Matt Prater | K | 2 | 0 | 0.0 | 0 | 0 | 0 |
| Khalil Shakir | WR | 2 | 2 | 0.0 | 0 | 0 | 0 |
| Mitch Wishnowsky | P | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Curtis Samuel | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Dawson Knox | TE | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Gabe Davis | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Damar Hamlin | SAF | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Josh Palmer | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |
| Ray Davis | RB | 1 | 0 | 0.0 | 0 | 0 | 0 |
| Keon Coleman | WR | 1 | 1 | 0.0 | 0 | 0 | 0 |